The novel therapeutic strategy of vilazodone-donepezil chimeras as potent triple-target ligands for the potential treatment of Alzheimer's disease with comorbid depression
文献类型：期刊论文
| 作者 | Li, Xiaokang1; Li, Jinwen1; Huang, Yunyuan1; Gong, Qi2; Fu, Yan2; Xu, Yixiang1; Huang, Junyang1; You, Haolan1; Zhang, Dong2; Zhang, Dan2 |
| 刊名 | EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY
 |
| 出版日期 | 2022-02-05 |
| 卷号 | 229页码:22 |
| ISSN号 | 0223-5234 |
| 关键词 | Alzheimer's disease Depression Comorbidity Multi-target-directed ligands |
| DOI | 10.1016/j.ejmech.2021.114045 |
| 通讯作者 | Wang, Huan(hwang1990@simm.ac.cn) ; Zhang, Haiyan(hzhang@simm.ac.cn) ; Li, Jian(jianli@ecust.edu.cn) |
| 英文摘要 | Depression is one of the most frequent comorbid psychiatric symptoms of Alzheimer's disease (AD), and no efficacious drugs have been approved specifically for this purpose thus far. Herein, we proposed a novel therapeutic strategy that merged the key pharmacophores of the antidepressant vilazodone (5-HT1A receptor partial agonist and serotonin transporter inhibitor) and the anti-AD drug donepezil (acetylcholinesterase inhibitor) together to develop a series of multi-target-directed ligands for potential therapy of the comorbidity of AD and depression. Accordingly, 55 vilazodone-donepezil chimeric derivatives were designed and synthesized, and their triple-target activities against acetylcholinesterase, 5-HT1A receptor, and serotonin transporter were systematically evaluated. Among them, compound 5 displayed strong triple-target bioactivities in vitro, low hERG potassium channel inhibition and accept-able brain distribution. Importantly, oral intake of 5 mg/kg of the compound 5 dihydrochloride significantly alleviated the depressive symptoms and ameliorated cognitive dysfunction in mouse models. In brief, these results highlight vilazodone-donepezil chimeras as a prospective therapeutic approach for the treatment of the comorbidity of AD and depression.& nbsp;(c) 2021 Elsevier Masson SAS. All rights reserved. |
| WOS关键词 | MULTITARGET-DIRECTED LIGANDS ; TAIL SUSPENSION TEST ; 5-HT1A RECEPTOR ; ACETYLCHOLINESTERASE INHIBITORS ; CHOLINERGIC HYPOTHESIS ; SEROTONIN ; DESIGN ; TRANSPORTER ; PREVALENCE ; DEMENTIA |
| 资助项目 | National Natural Science Foundation of China[81872747] ; National Natural Science Foundation of China[81903457] ; National Natural Science Foundation of China[22037002] ; National Natural Science Foundation of China[81903586] ; National Natural Science Foundation of China[82173689] ; National Science & Technology Major Projects of China[2018ZX09711002-013-006] ; National Mega-project for Innovative Drugs of China[2019ZX09721001-004-0 03] ; Shanghai Sailing Program[19YF1412600] ; Shanghai Morning Light Program[18CG33] ; Innovative Research Team of High-level Local Universities in Shanghai ; Chinese Special Fund for State Key Laboratory of Bioreactor Engineering[2060204] ; China Postdoctoral Science Foundation[(2018M642121] ; [2018M642121] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| 出版者 | ELSEVIER FRANCE-EDITIONS SCIENTIFIQUES MEDICALES ELSEVIER |
| WOS记录号 | WOS:000766121600014 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/299930]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Wang, Huan; Zhang, Haiyan; Li, Jian |
| 作者单位 | 1.East China Univ Sci & Technol, Frontiers Sci Ctr Mat & Dynam Chem, State Key Lab Bioreactor Engn, Sch Pharm,Shanghai Key Lab New Drug Design, 130 Mei Long Rd, Shanghai 200237, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, 555 Chong Zhi Rd, Shanghai 201203, Peoples R China 3.Dali Univ, Coll Pharm, Yunnan Key Lab Screening & Res Antipathogen Plant, 5 Xue Ren Rd, Dali 671000, Yunnan, Peoples R China 4.Tongji Univ, Sch Med, Shanghai Peoples Hosp 10, Clin Med Sci & Tech Innovat Ctr, Shanghai 200092, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Xiaokang,Li, Jinwen,Huang, Yunyuan,et al. The novel therapeutic strategy of vilazodone-donepezil chimeras as potent triple-target ligands for the potential treatment of Alzheimer's disease with comorbid depression[J]. EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,2022,229:22. |
| APA | Li, Xiaokang.,Li, Jinwen.,Huang, Yunyuan.,Gong, Qi.,Fu, Yan.,...&Li, Jian.(2022).The novel therapeutic strategy of vilazodone-donepezil chimeras as potent triple-target ligands for the potential treatment of Alzheimer's disease with comorbid depression.EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY,229,22. |
| MLA | Li, Xiaokang,et al."The novel therapeutic strategy of vilazodone-donepezil chimeras as potent triple-target ligands for the potential treatment of Alzheimer's disease with comorbid depression".EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY 229(2022):22. |
入库方式： OAI收割
来源：上海药物研究所
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