Rhodium(III)-Catalyzed Asymmetric 1,2-Carboamidation of Alkenes Enables Access to Chiral 2,3-Dihydro-3-benzofuranmethanamides
文献类型：期刊论文
| 作者 | Yu, Wenwen2,3; Chen, Chao1,2,3; Feng, Lei2,3; Xia, Tianqi3,4; Shi, Chen2,3; Yang, Yaxi2,3,4 ; Zhou, Bing2,3,4
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| 刊名 | ORGANIC LETTERS
 |
| 出版日期 | 2022-03-11 |
| 卷号 | 24期号:9页码:1762-1767 |
| ISSN号 | 1523-7060 |
| DOI | 10.1021/acs.orglett.2c00029 |
| 通讯作者 | Yang, Yaxi(yangyaxi@simm.ac.cn) ; Zhou, Bing(zhoubing@simm.ac.cn) |
| 英文摘要 | Through the initial screening and further rational design of chiral cydopentadienyl ligands, a chiral rhodium-catalyzed enantioselective 1,2-carboamidation of aromatic tethered alkenes was developed, enabling the asymmetric preparation of various chiral 2,3-dihydro-3-benzofuranmethanamides with an enantioenriched all-carbon quaternary center at the beta position of amide. This robust transformation has a broad functional group tolerance, excellent enantioselectivities (up to 98.5:1.5 er), and a mild reaction conditions, releasing CO2 as the single byproduct. |
| WOS关键词 | C-H FUNCTIONALIZATION ; CARBOAMINATION REACTIONS ; INTRAMOLECULAR HYDROARYLATION ; AROMATIC IMINES ; BOND FORMATION ; LIGANDS ; COMPLEXES ; ACTIVATION ; ALKYLATION ; CATALYSIS |
| 资助项目 | National Natural Science Foundation of China[81973166] ; National Natural Science Foundation of China[81773568] ; National Key R&D Program of China[2018YFA0508200] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000770063700002 |
| 出版者 | AMER CHEMICAL SOC |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/300009]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Yang, Yaxi; Zhou, Bing |
| 作者单位 | 1.Fudan Univ, Sch Pharm, Dept Med Chem, Shanghai 201203, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Dept Med Chem, State Key Lab Drug Res, Shanghai 201203, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Univ Chinese Acad Sci, Sch Pharmaceut Sci & Technol, Hangzhou Inst Adv Study, Hangzhou 310024, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yu, Wenwen,Chen, Chao,Feng, Lei,et al. Rhodium(III)-Catalyzed Asymmetric 1,2-Carboamidation of Alkenes Enables Access to Chiral 2,3-Dihydro-3-benzofuranmethanamides[J]. ORGANIC LETTERS,2022,24(9):1762-1767. |
| APA | Yu, Wenwen.,Chen, Chao.,Feng, Lei.,Xia, Tianqi.,Shi, Chen.,...&Zhou, Bing.(2022).Rhodium(III)-Catalyzed Asymmetric 1,2-Carboamidation of Alkenes Enables Access to Chiral 2,3-Dihydro-3-benzofuranmethanamides.ORGANIC LETTERS,24(9),1762-1767. |
| MLA | Yu, Wenwen,et al."Rhodium(III)-Catalyzed Asymmetric 1,2-Carboamidation of Alkenes Enables Access to Chiral 2,3-Dihydro-3-benzofuranmethanamides".ORGANIC LETTERS 24.9(2022):1762-1767. |
入库方式： OAI收割
来源：上海药物研究所
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