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New laboratory evidence for the association between endothelial dysfunction and COVID-19 disease progression

文献类型：期刊论文

作者Liu, Nan1,2; Long, Hui3; Sun, Jianhua1,2; Li, Huan3; He, Yunting4; Wang, Qiang5; Pan, Kai6; Tong, Yongliang1,2; Wang, Bingshun4; Wu, Qingming3,5
刊名JOURNAL OF MEDICAL VIROLOGY
出版日期2022-03-17
页码9
ISSN号0146-6615
关键词COVID-19 endothelial dysfunction laboratory evidence prognosis
DOI10.1002/jmv.27693
通讯作者Sun, Jianhua(jhsun@cdser.simm.ac.cn) ; Wang, Bingshun(wangbingshun@sjtu.edu.cn) ; Wu, Qingming(wuhe9224@sina.com) ; Gong, Likun(lkgong@cdser.simm.ac.cn)
英文摘要There is growing evidence that angiotensin-converting enzyme 2 is highly expressed on endothelial cells, endothelial dysfunction plays a critical role in coronavirus disease 2019 (COVID-19) progression, but laboratory evidence is still lacking. This study established a multicenter retrospective cohort of 966 COVID-19 patients from three hospitals in Wuhan, China. We found that male (62.8% vs. 46.5%), old age [72 (17) vs. 60.5 (21)], and coexisting chronic diseases (88.5% vs. 60.0%) were associated with poor clinical prognosis in COVID-19. Furthermore, the deteriorated patients exhibited more severe multiorgan damage, coagulation dysfunction, and extensive inflammation. Additionally, a cross-sectional study including 41 non-COVID-19 controls and 39 COVID-19 patients assayed endothelial function parameters in plasma and showed that COVID-19 patients exhibited elevated vascular cell adhesion molecule-1 (VCAM-1) (odds ratio: 1.000; 95% confidence interval [CI]: 1.000-1.000; p = 0.002), E-selectin (odds ratio: 1.000; 95% CI: 1.000-1.001; p < 0.001), tissue-type plasminogen activator (tPA) (odds ratio: 1.024; 95% CI: 1.014-1.035; p < 0.001), and decreased plasminogen activator inhibitor-1 (odds ratio: 0.995; 95% CI: 0.990-1.000; p = 0.059). Moreover, VCAM-1 was positively correlated with D-dimer (R = 0.544, p < 0.001); tPA was positively correlated with D-dimer (R = 0.800, p < 0.001) and blood urea nitrogen (R = 0.638, p < 0.001). Our findings further confirm the strong association between endothelial dysfunction and poor prognosis of COVID-19, which offers a rationale for targeting endothelial dysfunction as a therapeutic strategy for COVID-19.
WOS关键词SARS-COV-2 SPIKE
WOS研究方向Virology
语种英语
出版者WILEY
WOS记录号WOS:000769913100001
源URL[http://119.78.100.183/handle/2S10ELR8/300018]  
专题新药研究国家重点实验室
通讯作者Sun, Jianhua; Wang, Bingshun; Wu, Qingming; Gong, Likun
作者单位1.Chinese Acad Sci, Ctr Drug Safety Evaluat & Res, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai, Peoples R China
2.Univ Chinese Acad Sci, Sch Pharm, Beijing, Peoples R China
3.Wuhan Univ Sci & Technol, Tianyou Hosp, Med Coll, Wuhan, Peoples R China
4.Shanghai Jiao Tong Univ, Clin Res Inst, Sch Med, Dept Biostat, Shanghai 200025, Peoples R China
5.Wuhan Univ Sci & Technol, Med Coll, Inst Infect Immunol & Tumor Microenvironm, Hubei Prov Key Lab Occupat Hazard Identificat & C, Wuhan, Peoples R China
6.Hubei Prov Ctr Dis Control & Prevent, Div Viral Dis, Inst Hlth Inspect & Testing, Wuhan, Peoples R China
7.Chinese Acad Sci, Zhongshan Inst Drug Discovery, Shanghai Inst Mat Med, Zhongshan, Peoples R China
推荐引用方式
GB/T 7714		 Liu, Nan,Long, Hui,Sun, Jianhua,et al. New laboratory evidence for the association between endothelial dysfunction and COVID-19 disease progression[J]. JOURNAL OF MEDICAL VIROLOGY,2022:9.
APA Liu, Nan.,Long, Hui.,Sun, Jianhua.,Li, Huan.,He, Yunting.,...&Gong, Likun.(2022).New laboratory evidence for the association between endothelial dysfunction and COVID-19 disease progression.JOURNAL OF MEDICAL VIROLOGY,9.
MLA Liu, Nan,et al."New laboratory evidence for the association between endothelial dysfunction and COVID-19 disease progression".JOURNAL OF MEDICAL VIROLOGY (2022):9.

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来源：上海药物研究所

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