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A galacturonan from Dioscorea opposita Thunb. regulates fecal and impairs IL-1 and IL-6 expression in diarrhea mice

文献类型：期刊论文

作者Pan, Hao-Yu1,2; Zhang, Chun-Qian1; Zhang, Xiu-Qi1,4; Zeng, Hui1,4; Dong, Chun-Hong3; Chen, Xia1,2,4; Ding, Kan1,2,3,4
刊名GLYCOCONJUGATE JOURNAL
出版日期2022-02-01
卷号39期号:1页码:131-141
关键词Dioscorea opposita Homogalacturonan Gut microbiota Antibiotic-associated-diarrhea Intestinal flora regulation
ISSN号0282-0080
DOI10.1007/s10719-022-10053-z
通讯作者Dong, Chun-Hong(chunhong_dong@hactcm.edu.cn) ; Chen, Xia(xiachentiger@126.com) ; Ding, Kan(dingkan@simm.ac.cn)
英文摘要Antibiotic-associated diarrhea (AAD) is a common side-effect of antibiotic treatment resulting from an imbalance in the colonic bacteria. The hypothesis of this study is to ask whether polysaccharide from the rhizome of Dioscorea opposita which is recorded as conventional herbs and food for diarrhea treatment in Southeast Asia, may be an active compound against diarrhea induced by antibiotics. To address, firstly, a homogenous polysaccharide, DOP0.2-S-3 was characterized as a homogalacturonan containing linear repeating units of -> 4)-alpha-(D)-GalAp(1 -> 4)-alpha-(D)-GalAp(1 -> with the average molecular weight of 14 kDa. DOP0.2-S-3 significantly reduced the water content and defecation times caused by AAD in mice, while it also remarkably attenuated the cytokines of IL-1 beta and IL-6 expression in mice colon tissues. DOP0.2-S-3 decreased potential pathogen and increased Bacteroidetes in the mice gut. These results suggested DOP0.2-S-3 might be a new leading compound for the functional foods or drug candidate development against AAD partially through regulating gut flora.
WOS关键词ANTIBIOTIC-ASSOCIATED DIARRHEA ; PHYSICOCHEMICAL CHARACTERIZATION ; IMMUNOMODULATORY ACTIVITY ; INTESTINAL MICROBIOTA ; HOMOGALACTURONAN ; CHAIN
资助项目Key New Drug Creation and Manufacturing Program[2019ZX09735001] ; Ministry of Science and Technology, the People Republic of China ; National Natural Science Foundation of China[81903762]
WOS研究方向Biochemistry & Molecular Biology
语种英语
WOS记录号WOS:000768608800001
出版者SPRINGER
源URL[http://119.78.100.183/handle/2S10ELR8/300033]  
专题中国科学院上海药物研究所
通讯作者Dong, Chun-Hong; Chen, Xia; Ding, Kan
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, Glycochem & Glycobiol Lab, Key Lab Receptor Res, 555 Zu Chong Zhi Rd, Shanghai 201203, Peoples R China
2.Shanghai Univ Tradit Chinese Med, 1200 Cai Lun Rd, Shanghai 201203, Peoples R China
3.Henan Univ Tradit Chinese Med, Acad Chinese Med Sci, Henan Polysaccharide Res Ctr, Zhengzhou 450046, Henan, Peoples R China
4.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714		 Pan, Hao-Yu,Zhang, Chun-Qian,Zhang, Xiu-Qi,et al. A galacturonan from Dioscorea opposita Thunb. regulates fecal and impairs IL-1 and IL-6 expression in diarrhea mice[J]. GLYCOCONJUGATE JOURNAL,2022,39(1):131-141.
APA Pan, Hao-Yu.,Zhang, Chun-Qian.,Zhang, Xiu-Qi.,Zeng, Hui.,Dong, Chun-Hong.,...&Ding, Kan.(2022).A galacturonan from Dioscorea opposita Thunb. regulates fecal and impairs IL-1 and IL-6 expression in diarrhea mice.GLYCOCONJUGATE JOURNAL,39(1),131-141.
MLA Pan, Hao-Yu,et al."A galacturonan from Dioscorea opposita Thunb. regulates fecal and impairs IL-1 and IL-6 expression in diarrhea mice".GLYCOCONJUGATE JOURNAL 39.1(2022):131-141.

入库方式： OAI收割

来源：上海药物研究所

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