A drug-free nanozyme for mitigating oxidative stress and inflammatory bowel disease
文献类型：期刊论文
| 作者 | Zeng,Feng1; Shi,Yahong2; Wu,Chunni1; Liang,Jianming1; Zhong,Qixin15; Briley,Karen16; Xu,Bin14; Huang,Yongzhuo5,6,7 ; Long,Manmei11; Wang,Cong3,8
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| 刊名 | Journal of Nanobiotechnology
 |
| 出版日期 | 2022-03-04 |
| 卷号 | 20期号:1 |
| 关键词 | Ceria nanoparticles Reactive oxygen species Inflammatory bowel disease Macrophages Proinflammatory microenvironment |
| DOI | 10.1186/s12951-022-01319-7 |
| 通讯作者 | Xie,Jingyuan(nephroxie@163.com) ; Li,Cong(congli@fudan.edu.cn) ; Wu,Yingwei(wuyw0103@hotmail.com) |
| 英文摘要 | AbstractInflammatory bowel disease (IBD) is an incurable disease of the gastrointestinal tract with a lack of effective therapeutic strategies. The proinflammatory microenvironment plays a significant role in both amplifying and sustaining inflammation during IBD progression. Herein, biocompatible drug-free ceria nanoparticles (CeNP-PEG) with regenerable scavenging activities against multiple reactive oxygen species (ROS) were developed. CeNP-PEG exerted therapeutic effect in dextran sulfate sodium (DSS)-induced colitis murine model, evidenced by corrected the disease activity index, restrained colon length shortening, improved intestinal permeability and restored the colonic epithelium disruption. CeNP-PEG ameliorated the proinflammatory microenvironment by persistently scavenging ROS, down-regulating the levels of multiple proinflammatory cytokines, restraining the proinflammatory profile of macrophages and Th1/Th17 response. The underlying mechanism may involve restraining the co-activation of NF-κB and JAK2/STAT3 pathways. In summary, this work demonstrates an effective strategy for IBD treatment by ameliorating the self-perpetuating proinflammatory microenvironment, which offers a new avenue in the treatment of inflammation-related diseases.Graphical Abstract |
| 语种 | 英语 |
| WOS记录号 | BMC:10.1186/S12951-022-01319-7 |
| 出版者 | BioMed Central |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/300130]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Xie,Jingyuan; Li,Cong; Wu,Yingwei |
| 作者单位 | 1.The First Affiliated Hospital, The First Clinical Medical School, Lingnan Medical Research Center, Guangzhou University of Chinese Medicine; Artemisinin Research Center, Institute of Science and Technology 2.Shanghai Ninth People’s Hospital, Shanghai Jiao Tong University School of Medicine; Department of Radiology 3.Fudan University; Key Laboratory of Smart Drug Deliver, Ministry of Education, School of Pharmacy 4.Shanghai Ruijin Hospital, Shanghai Jiao Tong University School of Medicine; Department of Nephrology, Institute of Nephrology 5.Shanghai Institute of Materia Medica, Chinese Academy of Sciences 6.Chinese Academy of Sciences; Zhongshan Institute for Drug Discovery and Development 7.Taizhou University; School of Advanced Study, Institute of Natural Medicine and Health Product 8.Fudan University; China Academy for Engineering and Technology 9.Shanghai Ninth People’s Hospital, College of Stomatology, Shanghai Jiao Tong University School of Medicine; Laboratory of Oral Microbiota and Systemic Diseases 10.National Clinical Research Center for Oral Diseases, Shanghai Key Laboratory of Stomatology and Shanghai Research Institute of Stomatology |
| 推荐引用方式 GB/T 7714 | Zeng,Feng,Shi,Yahong,Wu,Chunni,et al. A drug-free nanozyme for mitigating oxidative stress and inflammatory bowel disease[J]. Journal of Nanobiotechnology,2022,20(1). |
| APA | Zeng,Feng.,Shi,Yahong.,Wu,Chunni.,Liang,Jianming.,Zhong,Qixin.,...&Wu,Yingwei.(2022).A drug-free nanozyme for mitigating oxidative stress and inflammatory bowel disease.Journal of Nanobiotechnology,20(1). |
| MLA | Zeng,Feng,et al."A drug-free nanozyme for mitigating oxidative stress and inflammatory bowel disease".Journal of Nanobiotechnology 20.1(2022). |
入库方式： OAI收割
来源：上海药物研究所
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