Eugenol restrains abdominal aortic aneurysm progression with down-regulations on NF-kappa B and COX-2
文献类型：期刊论文
| 作者 | Zhai, Ziyi2,3; Zhang, Xianjing2; Ding, Yuchao2,3; Huang, Ziming2; Li, Qian2,3; Zheng, Mingyue2 ; Cho, Kenka4; Dong, Zhihui1; Fu, Weiguo1; Chen, Zaixing3
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| 刊名 | PHYTOTHERAPY RESEARCH
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| 出版日期 | 2022-02-01 |
| 卷号 | 36期号:2页码:928-937 |
| ISSN号 | 0951-418X |
| 关键词 | abdominal aortic aneurysm COX-2 eugenol NF-kappa B |
| DOI | 10.1002/ptr.7358 |
| 通讯作者 | Chen, Zaixing(zaixingchen@sina.com) ; Jiang, Baohong(jiangbh@simm.ac.cn) |
| 英文摘要 | Abdominal aortic aneurysm (AAA) is a lethal disease without available medicine for treatment. This study aimed to evaluate the efficiency of eugenol (4-allyl-2-methoxyphenol) against AAA and the underlying mechanism. Eugenol is the major bioactive component of clove. A mouse AAA model was established through porcine pancreatic elastase (PPE) incubation peri-adventitially and 1% 3-aminopropanonitrile (BAPN) diet. Continuous AAA progression from day 0 to day 15 was observed after PPE plus BAPN treatment, according to the AAA diameter and histopathological evaluation. Accompanying with AAA progression, sustained increased expressions of CD68, COX-2 and NF-kappa B were observed through immunofluorescence assay. After elucidation the efficiency of eugenol against AAA progression by AAA diameter, hematoxylin-eosin staining and orcein staining, the down-regulations of eugenol on COX-2 and NF-kappa B were further detected by immunohistochemistry and western blot. Eugenol not only blocked AAA expansion and protected the integrity of aortic structure in a dose-dependent manner, but also held high oral bioavailability. Excellent efficiency, high oral bioavailability and down-regulation on COX-2/NF-kappa B endowed eugenol great potential for future AAA therapy. |
| WOS关键词 | VASCULAR-SURGERY ; SALVIANOLIC ACID ; MODEL ; INHIBITION ; GUIDELINES ; SOCIETY ; MICE |
| 资助项目 | National Natural Science Foundation of China[81770478] ; National Natural Science Foundation of China[81970395] ; Shanghai Science and Technology Development Foundation[21S21901900] ; Biological Resources Programme, Chinese Academy of Sciences[KFJ-BRP-008-005] ; Ministry of Science and Technology of China[2021YFE0111300] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| 出版者 | WILEY |
| WOS记录号 | WOS:000752203700001 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/300139]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Chen, Zaixing; Jiang, Baohong |
| 作者单位 | 1.Fudan Univ, Zhongshan Hosp, Shanghai, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Haike Rd 501, Shanghai 201203, Peoples R China 3.China Med Univ, Coll Pharm, Puhe Rd 77, Shenyang 110122, Liaoning, Peoples R China 4.Takarazuka Univ Med & Hlth Care, Dept Acupuncture, Takarazuka, Hyogo, Japan |
| 推荐引用方式 GB/T 7714 | Zhai, Ziyi,Zhang, Xianjing,Ding, Yuchao,et al. Eugenol restrains abdominal aortic aneurysm progression with down-regulations on NF-kappa B and COX-2[J]. PHYTOTHERAPY RESEARCH,2022,36(2):928-937. |
| APA | Zhai, Ziyi.,Zhang, Xianjing.,Ding, Yuchao.,Huang, Ziming.,Li, Qian.,...&Jiang, Baohong.(2022).Eugenol restrains abdominal aortic aneurysm progression with down-regulations on NF-kappa B and COX-2.PHYTOTHERAPY RESEARCH,36(2),928-937. |
| MLA | Zhai, Ziyi,et al."Eugenol restrains abdominal aortic aneurysm progression with down-regulations on NF-kappa B and COX-2".PHYTOTHERAPY RESEARCH 36.2(2022):928-937. |
入库方式： OAI收割
来源：上海药物研究所
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