Diversity-oriented synthesis of marine sponge derived hyrtioreticulins and their anti-inflammatory activities
文献类型：期刊论文
| 作者 | Chen Bo-Ru2,3; Gao Cheng-Long1; Liu Jin3; Guo Yue-Wei3,4 ; Jiang Jian-Lan2; Pang Tao1; Li Xu-Wen3,4
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| 刊名 | CHINESE JOURNAL OF NATURAL MEDICINES
 |
| 出版日期 | 2022 |
| 卷号 | 20期号:1页码:74-80 |
| 关键词 | Indole alkaloid Pictet-Spengler reaction Inflammation Hyrtioreticulin |
| ISSN号 | 2095-6975 |
| DOI | 10.1016/S1875-5364(22)60155-9 |
| 通讯作者 | Jiang Jian-Lan(jljiang@tju.edu.cn) ; Pang Tao(tpang@cpu.edu.cn) ; Li Xu-Wen(xwli@simm.ac.cn) |
| 英文摘要 | Diversity-oriented synthesis is aimed to increase the chemical diversity of target natural products for extensive biological activity evaluation. Indole ring is an important functional group in a large number of drugs and other biologically active agents, and indole-containing natural products have been frequently isolated from marine sources in recent years. In this paper, a series of in dole-containing marine natural hyrtioreticulin derivatives, including 19 new ones, were designed, synthesized through a key PictetSpengler reaction, and evaluated for their inflammation related activity. Compound 13b displayed the most promising activity by inhibiting TNF-alpha cytokine release with an inhibitory rate of 92% at a concentration of 20 mu mol.L-1. A preliminary structure-activity relationship analysis was also discussed. This research may throw light on the discovery of marine indole alkaloid derived anti-inflammatory drug leads. |
| WOS关键词 | PICTET-SPENGLER REACTION ; A-C ; ALKALOIDS ; DERIVATIVES |
| 资助项目 | National Natural Science Foundation of China[82022069] ; National Natural Science Foundation of China[81991521] ; National Natural Science Foundation of China[42076099] ; National Natural Science Foundation of China[81973512] ; Shanghai Rising-Star Program[20QA1411100] ; Open Project Program of the State Key Laboratory of Drug Research, Shanghai Institute of Materia Medica, Chinese Academy of Sciences[SIMM2004KF-08] |
| WOS研究方向 | Integrative & Complementary Medicine ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000749846000008 |
| 出版者 | CHINESE JOURNAL NATURAL MEDICINES |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/300147]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Jiang Jian-Lan; Pang Tao; Li Xu-Wen |
| 作者单位 | 1.China Pharmaceut Univ, New Drug Screening Ctr, State Key Lab Nat Med, Nanjing 210009, Peoples R China 2.Tianjin Univ, Sch Chem Engn & Technol, Tianjin 300350, Peoples R China 3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 4.Qingdao Natl Lab Marine Sci & Technol, Open Studio Druggabil Res Marine Nat Prod, Qingdao 266237, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen Bo-Ru,Gao Cheng-Long,Liu Jin,et al. Diversity-oriented synthesis of marine sponge derived hyrtioreticulins and their anti-inflammatory activities[J]. CHINESE JOURNAL OF NATURAL MEDICINES,2022,20(1):74-80. |
| APA | Chen Bo-Ru.,Gao Cheng-Long.,Liu Jin.,Guo Yue-Wei.,Jiang Jian-Lan.,...&Li Xu-Wen.(2022).Diversity-oriented synthesis of marine sponge derived hyrtioreticulins and their anti-inflammatory activities.CHINESE JOURNAL OF NATURAL MEDICINES,20(1),74-80. |
| MLA | Chen Bo-Ru,et al."Diversity-oriented synthesis of marine sponge derived hyrtioreticulins and their anti-inflammatory activities".CHINESE JOURNAL OF NATURAL MEDICINES 20.1(2022):74-80. |
入库方式： OAI收割
来源：上海药物研究所
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