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Phorneroids A-M, diverse types of diterpenoids from Euphorbia neriifolia

文献类型：期刊论文

作者Gao, Yuan1,4; Zhou, Jun-Su4; Liu, Hong-Chun4; Zhang, Yan4; Yin, Wei-Hang2,4; Liu, Qun-Fang4; Wang, Guan-Wu1,3; Zhao, Jin-Xin4; Yue, Jian-Min2,4
刊名PHYTOCHEMISTRY
出版日期2022-06-01
卷号198页码:11
ISSN号0031-9422
关键词Euphorbia neriifolia Euphorbiaceae Diterpenoid Ent-abietane Ent-kaurane Ent-atisane Ent-isopimarane Phorneroids A-M Cytotoxicity
DOI10.1016/j.phytochem.2022.113142
通讯作者Wang, Guan-Wu(gwang@ustc.edu.cn) ; Zhao, Jin-Xin(jxzhao@simm.ac.cn) ; Yue, Jian-Min(jmyue@simm.ac.cn)
英文摘要A chemical investigation on the aerial parts of Euphorbia neriifolia led to the identification of thirteen undescribed diterpenoids, phorneroids A-M, including ent-abietane (A-D), ent-kaurane (E-G), ent-atisane (H-K), and ent- isopimarane (L and M) types, together with three known compounds. Phorneroid A represents the first example of 8-spiro-fused 9,10-seco-ent-abietane diterpenoid lactone featuring a unique 6/5/6/5 spirocyclic framework. Biological assays showed that some of the compounds displayed moderate cytotoxicity against two human tumor cell lines, A549 and HL-60.
WOS关键词STEM BARK ; LACTONES ; PLANTS ; ROOTS
资助项目National Natural Science Foundation[81872758] ; CAMS Innovation Fund for Medical Sciences[2019I2M-5-080] ; Biological Resources Program of Chinese Academy of Sciences[KFJ-BRP-008-001]
WOS研究方向Biochemistry & Molecular Biology ; Plant Sciences
语种英语
出版者PERGAMON-ELSEVIER SCIENCE LTD
WOS记录号WOS:000765930400006
源URL[http://119.78.100.183/handle/2S10ELR8/300173]  
专题新药研究国家重点实验室
通讯作者Wang, Guan-Wu; Zhao, Jin-Xin; Yue, Jian-Min
作者单位1.Univ Sci & Technol China, Nano Sci & Technol Inst, Suzhou 215123, Jiangsu, Peoples R China
2.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China
3.Univ Sci & Technol China, Dept Chem, Hefei 230026, Anhui, Peoples R China
4.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Gao, Yuan,Zhou, Jun-Su,Liu, Hong-Chun,et al. Phorneroids A-M, diverse types of diterpenoids from Euphorbia neriifolia[J]. PHYTOCHEMISTRY,2022,198:11.
APA Gao, Yuan.,Zhou, Jun-Su.,Liu, Hong-Chun.,Zhang, Yan.,Yin, Wei-Hang.,...&Yue, Jian-Min.(2022).Phorneroids A-M, diverse types of diterpenoids from Euphorbia neriifolia.PHYTOCHEMISTRY,198,11.
MLA Gao, Yuan,et al."Phorneroids A-M, diverse types of diterpenoids from Euphorbia neriifolia".PHYTOCHEMISTRY 198(2022):11.

入库方式： OAI收割

来源：上海药物研究所

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