Divergent On-DNA Transformations from DNA-Linked Piperidones
文献类型：期刊论文
| 作者 | Ling, Xing1,4; Lu, Weiwei4; Miao, Lin2; Marcaurelle, Lisa A.3; Wang, Xuan4; Ding, Yun3; Lu, Xiaojie1,4
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| 刊名 | JOURNAL OF ORGANIC CHEMISTRY
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| 出版日期 | 2022-02-18 |
| 卷号 | 87期号:4页码:1971-1976 |
| ISSN号 | 0022-3263 |
| DOI | 10.1021/acs.joc.1c00670 |
| 通讯作者 | Wang, Xuan(wangxuan2@simm.ac.cn) ; Ding, Yun(yun.x.ding@gsk.com) ; Lu, Xiaojie(xjlu@simm.ac.cn) |
| 英文摘要 | A group of highly efficient and divergent transformations for constructing multiple DNA-linked chemotypes based on a piperidone core were successfully developed. We reported the first procedure for the synthesis of a DNA-conjugated piperidine intermediate under basic conditions. Subsequently, this substructure was subjected to additional reactions to generate several privileged scaffolds, including 4-aminopiperidine, fused [1,2,4]triazolo[1,5-a]pyrimidine, and a quinoline derivative. These transformations paved the way for constructing focused scaffold-based DNA-encoded libraries with druglike properties. |
| 资助项目 | NSFC[21877117] ; NSFC[91953203] ; National Science & Technology Major Project Key New Drug Creation and Manufacturing Program, China[2018ZX09711002-005] ; Shanghai Commission of Science and Technology[18431907100] ; [NSFC-21907103] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| 出版者 | AMER CHEMICAL SOC |
| WOS记录号 | WOS:000762795100008 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/300176]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Wang, Xuan; Ding, Yun; Lu, Xiaojie |
| 作者单位 | 1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 2.Univ Nottingham Ningbo China, Ningbo 315100, Zhejiang, Peoples R China 3.GlaxoSmithKline, ELT NCE Mol Discovery, Med Sci & Technol, Cambridge, MA 02410 USA 4.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ling, Xing,Lu, Weiwei,Miao, Lin,et al. Divergent On-DNA Transformations from DNA-Linked Piperidones[J]. JOURNAL OF ORGANIC CHEMISTRY,2022,87(4):1971-1976. |
| APA | Ling, Xing.,Lu, Weiwei.,Miao, Lin.,Marcaurelle, Lisa A..,Wang, Xuan.,...&Lu, Xiaojie.(2022).Divergent On-DNA Transformations from DNA-Linked Piperidones.JOURNAL OF ORGANIC CHEMISTRY,87(4),1971-1976. |
| MLA | Ling, Xing,et al."Divergent On-DNA Transformations from DNA-Linked Piperidones".JOURNAL OF ORGANIC CHEMISTRY 87.4(2022):1971-1976. |
入库方式： OAI收割
来源：上海药物研究所
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