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First Report on Inhibitory Effect against Osteoclastogenesis of Dihydro-beta-agarofuran-Type Sesquiterpenoids

文献类型：期刊论文

作者Ning, Ruonan2,4; Mu, Hongyan1,5; Chen, Li3,5; Wang, Tianqi2; Xu, Xing2; He, Shijun3,5; Jiang, Min2; Zhao, Weimin1,5
刊名JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY
出版日期2022-01-19
卷号70期号:2页码:554-566
关键词Celastraceae Celastrus monospermus Roxb osteoclastogenesis dihydro-beta-agarofuran sesquiterpenoid
ISSN号0021-8561
DOI10.1021/acs.jafc.1c06862
通讯作者He, Shijun(heshijun@ssimm.ac.cn) ; Jiang, Min(jiangm263@163.com) ; Zhao, Weimin(wmzhao@simm.ac.cn)
英文摘要Dihydro-beta-agarofuran-type sesquiterpenoids are characteristic metabolites of Celastraceae plants, and the extracts of these plants have been developed into botanical pesticides. In the course of our efforts to find novel natural biologically active products, eight new dihydro-beta-agarofuran-type sesquiterpenoids (1-8) were identified from the stems of Celastrus monospermus Roxb. Their structures were elucidated by extensive spectroscopic analysis, single crystal X-ray crystallography, and electronic circular dichroism (ECD) calculations. In consideration of the efficacy of certain Celastrus plants for the treatment of arthritis and arthralgia in folk medicine, the isolates were evaluated for their inhibitory activities against osteoclastogenesis. As a result, compounds 4, 6, and 7 were found to restrain osteoclastogenesis induced by receptor activator of nuclear factor-kappa B ligand (RANKL) with IC50 values of 0.58, 1.2, and 6.1 mu M, respectively. Furthermore, compound 4 was found to inhibit osteoclastogenesis-related gene (c-Fos, MMP-9, CTSK, TRAP) expression and block c-Fos protein expression and inhibited bone resorption of mature osteoclasts induced by M-CSF and RANKL in a dose dependent manner. This is the first report of dihydro-beta-agarofuran-type sesquiterpenoid for their potential medical applications in bone metabolic diseases.
WOS关键词CELASTRUS-PANICULATUS ; PLANTS ; SEEDS ; DIFFERENTIATION ; AGENTS
资助项目Shanghai Sailing Program[20YF1418300] ; Shanghai Municipal Health Commission[20184Y0138] ; Teacher's Professional Development Project of Shanghai Municipal Education Commission[A3-2601-20-311001-8] ; Science and Technology Commission of Shanghai Municipality[21S11907700] ; Shanghai Municipal Science Technology Major Project
WOS研究方向Agriculture ; Chemistry ; Food Science & Technology
语种英语
WOS记录号WOS:000763529200012
出版者AMER CHEMICAL SOC
源URL[http://119.78.100.183/handle/2S10ELR8/300182]  
专题新药研究国家重点实验室
通讯作者He, Shijun; Jiang, Min; Zhao, Weimin
作者单位1.Chinese Acad Sci, Nat Prod Res Ctr, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
2.Shanghai Jiao Tong Univ, Ruijin Hosp, Shanghai Inst Traumatol & Orthopaed, Dept Orthopaed,Sch Med, Shanghai 200025, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Mat Med, Lab Immunopharmacol, State Key Lab Drug Res, Shanghai 201203, Peoples R China
4.Shanghai Univ Med & Hlth Sci, Sch Pharm, Shanghai 201318, Peoples R China
5.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714		 Ning, Ruonan,Mu, Hongyan,Chen, Li,et al. First Report on Inhibitory Effect against Osteoclastogenesis of Dihydro-beta-agarofuran-Type Sesquiterpenoids[J]. JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,2022,70(2):554-566.
APA Ning, Ruonan.,Mu, Hongyan.,Chen, Li.,Wang, Tianqi.,Xu, Xing.,...&Zhao, Weimin.(2022).First Report on Inhibitory Effect against Osteoclastogenesis of Dihydro-beta-agarofuran-Type Sesquiterpenoids.JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY,70(2),554-566.
MLA Ning, Ruonan,et al."First Report on Inhibitory Effect against Osteoclastogenesis of Dihydro-beta-agarofuran-Type Sesquiterpenoids".JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY 70.2(2022):554-566.

入库方式： OAI收割

来源：上海药物研究所

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