Cofactor-Driven Cascade Reactions Enable the Efficient Preparation of Sugar Nucleotides
文献类型：期刊论文
| 作者 | Zheng, Yuan2; Zhang, Jiabin2,4; Meisner, Jeffrey1; Li, Wanjin2; Luo, Yawen2,3; Wei, Fangyu2,3; Wen, Liuqing2,3 |
| 刊名 | ANGEWANDTE CHEMIE-INTERNATIONAL EDITION
 |
| 出版日期 | 2022-03-10 |
| 页码 | 9 |
| ISSN号 | 1433-7851 |
| 关键词 | Biocatalysis Cascade Reactions One-Pot Reactions Sugar Nucleotides |
| DOI | 10.1002/anie.202115696 |
| 通讯作者 | Wen, Liuqing(lwen@simm.ac.cn) |
| 英文摘要 | Glycosylation is catalyzed by glycosyltransferases using sugar nucleotides or occasionally lipid-linked phosphosugars as donors. However, only very few common sugar nucleotides that occur in humans can be obtained readily, while the majority of sugar nucleotides that exist in bacteria, plants, archaea, or viruses cannot be synthesized in sufficient quantities by either enzymatic or chemical synthesis. The limited availability of such rare sugar nucleotides is one of the major obstacles that has greatly hampered progress in glycoscience. Herein we describe a general cofactor-driven cascade conversion strategy for the efficient synthesis of sugar nucleotides. The described strategy allows the large-scale preparation of rare sugar nucleotides from common sugars in high yields and without the need for tedious purification processes. |
| WOS关键词 | LARGE-SCALE PRODUCTION ; DEHYDROGENASE-CATALYZED REGENERATION ; UDP-N-ACETYLGLUCOSAMINE ; O-ANTIGEN BIOSYNTHESIS ; IN-VITRO BIOSYNTHESIS ; ENZYMATIC-SYNTHESIS ; NAD(P)-DEPENDENT OXIDOREDUCTASES ; CHEMOENZYMATIC SYNTHESIS ; GLUCOSE-DEHYDROGENASE ; GLYCAN BIOSYNTHESIS |
| 资助项目 | National Natural Science Foundation of China[22007092] ; Shanghai Sailing Program[20YF1457200] ; CAS Program[2021000027] ; Shanghai Municipal Science and Technology Major Project |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| WOS记录号 | WOS:000767106300001 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/300188]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Wen, Liuqing |
| 作者单位 | 1.Kaleido Biosci, Lexington, MA 02421 USA 2.Chinese Acad Sci, Shanghai Inst Mat Media, Carbohydrate Based Drug Res Ctr, Shanghai 201203, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Mat Media, Zhongshan Inst Drug Discovery, Zhongshan 528400, Guangdong, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zheng, Yuan,Zhang, Jiabin,Meisner, Jeffrey,et al. Cofactor-Driven Cascade Reactions Enable the Efficient Preparation of Sugar Nucleotides[J]. ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,2022:9. |
| APA | Zheng, Yuan.,Zhang, Jiabin.,Meisner, Jeffrey.,Li, Wanjin.,Luo, Yawen.,...&Wen, Liuqing.(2022).Cofactor-Driven Cascade Reactions Enable the Efficient Preparation of Sugar Nucleotides.ANGEWANDTE CHEMIE-INTERNATIONAL EDITION,9. |
| MLA | Zheng, Yuan,et al."Cofactor-Driven Cascade Reactions Enable the Efficient Preparation of Sugar Nucleotides".ANGEWANDTE CHEMIE-INTERNATIONAL EDITION (2022):9. |
入库方式： OAI收割
来源：上海药物研究所
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