Dihydro-beta-agarofuran-type sesquiterpenoids from the seeds of Celastrus virens with lifespan-extending effect on the nematode Caenorhabditis elegans
文献类型：期刊论文
| 作者 | Mu, Hong-Yan1,2; Gao, Ye-Hui3; Cao, Guang-Chao1,2; Jiang, Jin-Yun3; Wang, Hong-Bing3; Zhao, Wei-Min1,2
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| 刊名 | FITOTERAPIA
 |
| 出版日期 | 2022-04-01 |
| 卷号 | 158页码:11 |
| 关键词 | Dihydro-beta-agarofuran-type sesquiterpenoids Celastrus virens Lifespan Caenorhabditis elegans Key transcription factors |
| ISSN号 | 0367-326X |
| DOI | 10.1016/j.fitote.2022.105165 |
| 通讯作者 | Wang, Hong-Bing(hbwang@tongji.edu.cn) ; Zhao, Wei-Min(wmzhao@simm.ac.cn) |
| 英文摘要 | Twelve dihydro-beta-agamfuran-type sesquiterpenoids, including five new ones (1-5), were purified from the seeds of Celastrus virens (Wang et Tang) C. Y. Chent et T. C. Kao. Their chemical structures were characterized via comprehensive spectroscopic analysis, single-crystal X-ray diffraction analysis, and computational prediction of ECD, as well as comparison of observed and reported NMR spectral data. Among the isolates, nine abundant dihydro-beta-agarofuran-type sesquiterpenoids were evaluated for their lifespan-extending activity using the nematode Caenorhabditis elegans model. As a result, compounds 1, 2, 5, 6, 8, and 9 (50 mu M) significantly extended the mean survival time of C. elegans, respectively, compared with the blank control group (p < 0.05). Further Quantitative RT-PCR showed that the prolonging of lifespan mediated by compounds 1, 6, 8, and 9 were dependent on the transcription factors skn-1 and hsf-1. |
| WOS关键词 | SENESCENT CELLS ; AGE ; OSTEOPOROSIS |
| 资助项目 | National Key Research and Development Program of China[2019YFC1711300] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000761407800013 |
| 出版者 | ELSEVIER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/300215]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Wang, Hong-Bing; Zhao, Wei-Min |
| 作者单位 | 1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Nat Prod Res Ctr, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 3.Tongji Univ, Putuo Peoples Hosp, Sch Life Sci & Technol, Shanghai 200092, Peoples R China |
| 推荐引用方式 GB/T 7714 | Mu, Hong-Yan,Gao, Ye-Hui,Cao, Guang-Chao,et al. Dihydro-beta-agarofuran-type sesquiterpenoids from the seeds of Celastrus virens with lifespan-extending effect on the nematode Caenorhabditis elegans[J]. FITOTERAPIA,2022,158:11. |
| APA | Mu, Hong-Yan,Gao, Ye-Hui,Cao, Guang-Chao,Jiang, Jin-Yun,Wang, Hong-Bing,&Zhao, Wei-Min.(2022).Dihydro-beta-agarofuran-type sesquiterpenoids from the seeds of Celastrus virens with lifespan-extending effect on the nematode Caenorhabditis elegans.FITOTERAPIA,158,11. |
| MLA | Mu, Hong-Yan,et al."Dihydro-beta-agarofuran-type sesquiterpenoids from the seeds of Celastrus virens with lifespan-extending effect on the nematode Caenorhabditis elegans".FITOTERAPIA 158(2022):11. |
入库方式： OAI收割
来源：上海药物研究所
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