Decreased SLC27A5 Suppresses Lipid Synthesis and Tyrosine Metabolism to Activate the Cell Cycle in Hepatocellular Carcinoma
文献类型：期刊论文
| 作者 | Wang, Jiyan2,3; Qiao, Yaya2,3; Sun, Huanran2,3; Chang, Hongkai2,3; Zhao, Huifang4; Zhang, Shuai4; Shan, Changliang1,2,3 |
| 刊名 | BIOMEDICINES
 |
| 出版日期 | 2022-02-01 |
| 卷号 | 10期号:2页码:14 |
| 关键词 | hepatocellular carcinoma tyrosine metabolism lipids synthesis cell cycle |
| DOI | 10.3390/biomedicines10020234 |
| 通讯作者 | Zhang, Shuai(shuaizhang@tjutcm.edu.cn) ; Shan, Changliang(changliangshan@nankai.edu.cn) |
| 英文摘要 | Tyrosine is an essential ketogenic and glycogenic amino acid for the human body, which means that tyrosine is not only involved in protein metabolism, but also participates in the metabolism of lipids and carbohydrates. The liver is an important place for metabolism of lipids, carbohydrates, and proteins. The metabolic process of biological macro-molecules is a basis for maintaining the physiological activities of organisms, but the cross-linking mechanism of these processes is still unclear. Here, we found that the tyrosine-metabolizing enzymes, which were specifically and highly expressed in the liver, were significantly down-regulated in hepatocellular carcinoma (HCC), and had a correlation with a poor prognosis of HCC patients. Further analysis found that the reduction of tyrosine metabolism would activate the cell cycle and promote cell proliferation. In addition, we also found that the solute carrier family 27 member 5 (SLC27A5) regulates the expression of tyrosine-metabolizing enzymes through nuclear factor erythroid 2-related factor 2 (NRF2). Therefore, the SLC27A5 and tyrosine-metabolizing enzymes that we have identified coordinate lipid and tyrosine metabolism, regulate the cell cycle, and are potential targets for cancer treatment. |
| WOS关键词 | BIOMARKERS ; CANCER ; FATP5 ; MODEL |
| 资助项目 | National Nature Science Foundation of China[81973356] ; National Nature Science Foundation of China[81902826] ; National Nature Science Foundation of China[81672781] ; Fundamental Research Funds for the Central Universities of Nankai University[3206054] ; Fundamental Research Funds for the Central Universities of Nankai University[91923101] ; Fundamental Research Funds for the Central Universities of Nankai University[63213082] ; Fundamental Research Funds for the Central Universities of Nankai University[92122017] ; State Key Laboratory of Drug Research[SIMM2105KF-08] ; National Key R&D Program of China[2018YFC2002000] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Research & Experimental Medicine ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000763756100001 |
| 出版者 | MDPI |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/300230]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Zhang, Shuai; Shan, Changliang |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 2.Nankai Univ, Coll Pharm, State Key Lab Med Chem Biol, Tianjin 300350, Peoples R China 3.Nankai Univ, Tianjin Key Lab Mol Drug Res, Tianjin 300350, Peoples R China 4.Tianjin Univ Tradit Chinese Med, Sch Integrat Med, Tianjin 301617, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Jiyan,Qiao, Yaya,Sun, Huanran,et al. Decreased SLC27A5 Suppresses Lipid Synthesis and Tyrosine Metabolism to Activate the Cell Cycle in Hepatocellular Carcinoma[J]. BIOMEDICINES,2022,10(2):14. |
| APA | Wang, Jiyan.,Qiao, Yaya.,Sun, Huanran.,Chang, Hongkai.,Zhao, Huifang.,...&Shan, Changliang.(2022).Decreased SLC27A5 Suppresses Lipid Synthesis and Tyrosine Metabolism to Activate the Cell Cycle in Hepatocellular Carcinoma.BIOMEDICINES,10(2),14. |
| MLA | Wang, Jiyan,et al."Decreased SLC27A5 Suppresses Lipid Synthesis and Tyrosine Metabolism to Activate the Cell Cycle in Hepatocellular Carcinoma".BIOMEDICINES 10.2(2022):14. |
入库方式： OAI收割
来源：上海药物研究所
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