Snapshots of RNA polymerase III in action - A mini review
文献类型：期刊论文
| 作者 | Wang, Qianmin2,3,4; Daiss, Julia L.1; Xu, Youwei5; Engel, Christoph1 |
| 刊名 | GENE
 |
| 出版日期 | 2022-05-05 |
| 卷号 | 821页码:9 |
| ISSN号 | 0378-1119 |
| DOI | 10.1016/j.gene.2022.146282 |
| 通讯作者 | Xu, Youwei(xuyouwei@simm.ac.cn) ; Engel, Christoph(christoph.engel@ur.de) |
| 英文摘要 | RNA polymerase (Pol) III is responsible for the transcription of tRNAs, 5S rRNA, U6 snRNA, and other non-coding RNAs. Transcription factors such as TFIIIA, -B, -C, SNAPc, and Maf1 are required for promoter recognition, promoter opening, and Pol III activity regulation. Recent developments in cryo-electron microscopy and advanced purification approaches for endogenous multi-subunit complexes accelerated structural studies resulting in detailed structural insights which allowed an in-depth understanding of the molecular mechanisms underlying Pol III transcription. Here, we summarize structural data on Pol III and its regulating factors providing a three-dimensional framework to guide further analysis of RNA polymerase III. |
| WOS关键词 | INTERNAL CONTROL REGION ; CRYO-EM STRUCTURES ; TRANSCRIPTION INITIATION ; CRYSTAL-STRUCTURE ; ZINC FINGERS ; STRUCTURAL INSIGHTS ; MOLECULAR-STRUCTURES ; SUBCOMPLEX ; TERMINATION ; SUBUNITS |
| 资助项目 | National Natural Science Foundation of China[31900855] ; National Natural Science Foundation of China[81902085] ; Shanghai Pujiang Program[19PJ1407200] ; Key tasks of LG laboratory[LG202101-01-03] ; Emmy-Noether Programm[EN 1204/1-1] ; Emmy-Noether Programm[SFB 960 (TP-A8)] ; German Research Council ('Deutsche Forschungsgemeinschaft`) |
| WOS研究方向 | Genetics & Heredity |
| 语种 | 英语 |
| WOS记录号 | WOS:000755658000002 |
| 出版者 | ELSEVIER |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/300300]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Xu, Youwei; Engel, Christoph |
| 作者单位 | 1.Univ Regensburg, Regensburg Ctr Biochem, D-93053 Regensburg, Germany 2.Shanghai Jiao Tong Univ, Peoples Hosp 9, State Key Lab Oncogenes & Related Genes, Sch Med, Shanghai, Peoples R China 3.Shanghai Inst Precis Med, Shanghai, Peoples R China 4.Fudan Univ, Inst Biomed Sci, Shanghai 200032, Peoples R China 5.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, Shanghai, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Qianmin,Daiss, Julia L.,Xu, Youwei,et al. Snapshots of RNA polymerase III in action - A mini review[J]. GENE,2022,821:9. |
| APA | Wang, Qianmin,Daiss, Julia L.,Xu, Youwei,&Engel, Christoph.(2022).Snapshots of RNA polymerase III in action - A mini review.GENE,821,9. |
| MLA | Wang, Qianmin,et al."Snapshots of RNA polymerase III in action - A mini review".GENE 821(2022):9. |
入库方式： OAI收割
来源：上海药物研究所
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