Cephalotane-Type Norditerpenoids from Cephalotaxus fortunei var. alpina
文献类型：期刊论文
| 作者 | Ge, Zhan-Peng1; Zhou, Bin1; Zimbres, Flavia M.2; Cassera, Maria B.2; Zhao, Jin-Xin1; Yue, Jian-Min1
|
| 刊名 | CHINESE JOURNAL OF CHEMISTRY
 |
| 出版日期 | 2022-02-22 |
| 页码 | 1177-1184 |
| ISSN号 | 1001-604X |
| 关键词 | Cephalotaxus fortunei var alpine Natural products Structural elucidation Cephalotane norditerpenoids Antimalarial activity |
| DOI | 10.1002/cjoc.202100913 |
| 通讯作者 | Zhao, Jin-Xin(jxzhao@simm.ac.cn) ; Yue, Jian-Min(jmyue@simm.ac.cn) |
| 英文摘要 | Comprehensive Summary A chemical investigation of the 95% EtOH extract of the seeds of Cephalotaxus fortunei var. alpina led to the isolation of nine new cephalotane-type norditerpenoids, ceforalides A-I (1-9), and two known analogues (10 and 11). Compounds 1-8 belong to a rare class of A-ring-contracted cephalotane-type norditerpenoids, of which compound 8 incorporates a unique tetrasubstituted 2,5-cyclohexadienone A-ring. Compound 9 is a rare 13,14-seco-17-nor-cephalotane-type diterpenoid. Their structures were determined based on NMR, HRESIMS, ECD, and X-ray diffraction analysis. Biological tests revealed compounds 10 and 11 displayed moderate antimalarial activity. |
| WOS关键词 | A-D |
| 资助项目 | National Natural Science Foundation of China[81872758] ; National Natural Science Foundation of China[21907099] ; Science and Technology Commission of Shanghai Municipality[19YF1457000] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| WOS记录号 | WOS:000758743700001 |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/300303]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Zhao, Jin-Xin; Yue, Jian-Min |
| 作者单位 | 1.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China 2.Univ Georgia, Ctr Trop & Emerging Global Dis CTEGD, Dept Biochem & Mol Biol, Athens, GA 30602 USA |
| 推荐引用方式 GB/T 7714 | Ge, Zhan-Peng,Zhou, Bin,Zimbres, Flavia M.,et al. Cephalotane-Type Norditerpenoids from Cephalotaxus fortunei var. alpina[J]. CHINESE JOURNAL OF CHEMISTRY,2022:1177-1184. |
| APA | Ge, Zhan-Peng,Zhou, Bin,Zimbres, Flavia M.,Cassera, Maria B.,Zhao, Jin-Xin,&Yue, Jian-Min.(2022).Cephalotane-Type Norditerpenoids from Cephalotaxus fortunei var. alpina.CHINESE JOURNAL OF CHEMISTRY,1177-1184. |
| MLA | Ge, Zhan-Peng,et al."Cephalotane-Type Norditerpenoids from Cephalotaxus fortunei var. alpina".CHINESE JOURNAL OF CHEMISTRY (2022):1177-1184. |
入库方式： OAI收割
来源：上海药物研究所
浏览0
下载0
收藏0
其他版本
除非特别说明，本系统中所有内容都受版权保护，并保留所有权利。