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Bioinspired Lipoproteins of Furoxans-Oxaliplatin Remodel Physical Barriers in Tumor to Potentiate T-Cell Infiltration

文献类型：期刊论文

作者Wang, Yuqi2,3; Xie, Honglei4; Wu, Yao2; Xu, Shuzhou4; Li, Yongping1; Li, Jie2; Xu, Xiaoxuan2; Wang, Siling3; Li, Yaping2,5; Zhang, Zhiwen2,4
刊名ADVANCED MATERIALS
出版日期2022-02-26
页码12
ISSN号0935-9648
关键词bioinspired lipoprotein lymphocyte infiltration nitric oxide tumor stroma barrier tumor vessel normalization
DOI10.1002/adma.202110614
通讯作者Wang, Siling(silingwang@syphu.edu.cn) ; Li, Yaping(ypli@simm.ac.cn) ; Zhang, Zhiwen(zwzhang0125@simm.ac.cn)
英文摘要The infiltration of cytotoxic T lymphocytes (CTLs) in tumors is critically challenged by the intricate intratumor physical barriers, which is emerging as an important issue of anticancer immunotherapy. Herein, a reduction-sensitive nitric oxide donor conjugate of furoxans-oxaliplatin is synthesized and a stroma-cell-accessible bioinspired lipoprotein system (S-LFO) is designed, aiming to facilitate CTL infiltration in tumors for anticancer immunotherapy. S-LFO treatment significantly promotes tumor vessel normalization and eliminates multiple components of tumor stroma, ultimately producing a 2.96-fold, 5.02-fold, and 8.65-fold increase of CD3(+)CD8(+) T cells, their interferon-gamma- and granzyme B-expressing subtypes when comparing to the negative control, and considerably facilitating their trafficking to the cancer cell regions in tumors. Moreover, the combination of S-LFO with an antiprogrammed death ligand-1 produces notable therapeutic benefits of retarded tumor growth and extends survivals in three murine tumor models. Therefore, this study provides an encouraging strategy of remodeling the intratumor physical barriers to potentiate CTL infiltration for anticancer immunotherapy.
WOS关键词NITRIC-OXIDE ; BLOOD-VESSELS ; CHEMOTHERAPY ; IMMUNITY
资助项目National Natural Science Foundation of China[32071385] ; National Natural Science Foundation of China[31771092] ; National Natural Science Foundation of China[31930066] ; Shandong Provincial Natural Science Foundation of China[ZR2019ZD25] ; Fudan-SIMM Joint Research Fund[FU-SIMM20182005] ; China Postdoctoral Science Foundation[2021M693271] ; Clinical Trial Ethics Committee of Shanghai Pudong Hospital[WZ-016]
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种英语
出版者WILEY-V C H VERLAG GMBH
WOS记录号WOS:000761175200001
源URL[http://119.78.100.183/handle/2S10ELR8/300306]  
专题新药研究国家重点实验室
通讯作者Wang, Siling; Li, Yaping; Zhang, Zhiwen
作者单位1.Fudan Univ, Shanghai Pudong Hosp, Dept Breast Surg, Pudong Med Ctr, Shanghai 201399, Peoples R China
2.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
3.Shenyang Pharmaceut Univ, Sch Pharm, Shenyang 110016, Liaoning, Peoples R China
4.Yantai Inst Mat Med, Yantai Key Lab Nanomed & Adv Preparat, Yantai 264000, Shandong, Peoples R China
5.Bohai Rim Adv Res Inst Drug Discovery, Yantai 264005, Shandong, Peoples R China
推荐引用方式
GB/T 7714		 Wang, Yuqi,Xie, Honglei,Wu, Yao,et al. Bioinspired Lipoproteins of Furoxans-Oxaliplatin Remodel Physical Barriers in Tumor to Potentiate T-Cell Infiltration[J]. ADVANCED MATERIALS,2022:12.
APA Wang, Yuqi.,Xie, Honglei.,Wu, Yao.,Xu, Shuzhou.,Li, Yongping.,...&Zhang, Zhiwen.(2022).Bioinspired Lipoproteins of Furoxans-Oxaliplatin Remodel Physical Barriers in Tumor to Potentiate T-Cell Infiltration.ADVANCED MATERIALS,12.
MLA Wang, Yuqi,et al."Bioinspired Lipoproteins of Furoxans-Oxaliplatin Remodel Physical Barriers in Tumor to Potentiate T-Cell Infiltration".ADVANCED MATERIALS (2022):12.

入库方式： OAI收割

来源：上海药物研究所

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