Xishaeleganins A-D, Sesquiterpenoid Hydroquinones from Xisha Marine Sponge Dactylospongia elegans
文献类型：期刊论文
| 作者 | Chen, Bao1,2; Zhao, Qingmin1,3; Gu, Yu-Cheng4; Lan, Lefu1,3 ; Wang, Chang-Yun2; Guo, Yue-Wei1,5
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| 刊名 | MARINE DRUGS
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| 出版日期 | 2022-02-01 |
| 卷号 | 20期号:2页码:12 |
| 关键词 | sponge Dactylospongia elegans Thorectida antibacterial sesquiterpene hydroquinones |
| DOI | 10.3390/md20020118 |
| 通讯作者 | Lan, Lefu(llan@simm.ac.cn) ; Wang, Chang-Yun(changyun@ouc.edu.cn) ; Guo, Yue-Wei(ywguo@simm.ac.cn) |
| 英文摘要 | Four new sesquiterpene hydroquinones, xishaeleganins A-D (6-9), along with eleven known related ones (12 and 14-23) were isolated from the Xisha marine sponge Dactylospongia elegans (family Thorectida). Their structures were determined by extensive spectroscopic analysis, ECD calculations, and by comparison with the spectral data reported in the literature. Compounds 7, 15, 20, and 21 showed significant antibacterial activity against Staphylococcus aureus, with minimum inhibitory concentration values of 1.5, 2.9, 5.6, and 5.6 mu g/mL, which are comparable with those obtained for the positive control vancomycin (MIC: 1.0 mu g/mL). |
| WOS关键词 | HUMAN-IMMUNODEFICIENCY ; QUINONES ; AVAROL ; INHIBITION ; MEROTERPENOIDS ; SMENOSPONGINE ; AMINOQUINONE ; VIRUS |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000763619000001 |
| 出版者 | MDPI |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/300315]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Lan, Lefu; Wang, Chang-Yun; Guo, Yue-Wei |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Zu Chong Zhi Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China 2.Ocean Univ China, Sch Med & Pharm, Key Lab Marine Drugs, Minist Educ China, Qingdao 266003, Peoples R China 3.Univ Chinese Acad Sci, 19A Yuquan Rd, Beijing 100049, Peoples R China 4.Syngenta, Jealotts Hill Int Res Ctr, Bracknell RG42 6EY, Berks, England 5.Bohai Rim Adv Res Inst Drug Discovery, 198 Binhai East Rd, Yantai 264000, Peoples R China |
| 推荐引用方式 GB/T 7714 | Chen, Bao,Zhao, Qingmin,Gu, Yu-Cheng,et al. Xishaeleganins A-D, Sesquiterpenoid Hydroquinones from Xisha Marine Sponge Dactylospongia elegans[J]. MARINE DRUGS,2022,20(2):12. |
| APA | Chen, Bao,Zhao, Qingmin,Gu, Yu-Cheng,Lan, Lefu,Wang, Chang-Yun,&Guo, Yue-Wei.(2022).Xishaeleganins A-D, Sesquiterpenoid Hydroquinones from Xisha Marine Sponge Dactylospongia elegans.MARINE DRUGS,20(2),12. |
| MLA | Chen, Bao,et al."Xishaeleganins A-D, Sesquiterpenoid Hydroquinones from Xisha Marine Sponge Dactylospongia elegans".MARINE DRUGS 20.2(2022):12. |
入库方式： OAI收割
来源：上海药物研究所
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