The Multiple Roles of Glucose-6-Phosphate Dehydrogenase in Tumorigenesis and Cancer Chemoresistance
文献类型：期刊论文
| 作者 | Song, Jiaqi1,2; Sun, Huanran1,2; Zhang, Shuai3; Shan, Changliang1,2,4 |
| 刊名 | LIFE-BASEL
 |
| 出版日期 | 2022-02-01 |
| 卷号 | 12期号:2页码:19 |
| 关键词 | G6PD tumorigenesis chemotherapy resistance inhibitor metabolism enzyme |
| DOI | 10.3390/life12020271 |
| 通讯作者 | Zhang, Shuai(shuaizhang@tjutcm.edu.cn) ; Shan, Changliang(changliangshan@nankai.edu.cn) |
| 英文摘要 | The pentose phosphate pathway (PPP) is a branch from glycolysis that begins from glucose-6-phosphate (G6P) and ends up with fructose-6-phosphate (F6P) and glyceraldehyde-3-phosphate (GADP). Its primary physiological significance is to provide nicotinamide adenine dinucleotide phosphate (NADPH) and nucleotides for vital activities such as reactive oxygen species (ROS) defense and DNA synthesis. Glucose-6-phosphate dehydrogenase (G6PD) is a housekeeping protein with 514 amino acids that is also the rate-limiting enzyme of PPP, catalyzing G6P into 6-phosphogluconolactone (6PGL) and producing the first NADPH of this pathway. Increasing evidence indicates that G6PD is upregulated in diverse cancers, and this dysfunction influences DNA synthesis, DNA repair, cell cycle regulation and redox homeostasis, which provides advantageous conditions for cancer cell growth, epithelial-mesenchymal transition (EMT), invasion, metastasis and chemoresistance. Thus, targeting G6PD by inhibitors has been shown as a promising strategy in treating cancer and reversing chemotherapeutic resistance. In this review, we will summarize the existing knowledge concerning G6PD and discuss its role, regulation and inhibitors in cancer development and chemotherapy resistance. |
| WOS关键词 | PENTOSE-PHOSPHATE PATHWAY ; LEUCONOSTOC-MESENTEROIDES ; CELL CARCINOMA ; INHIBITS GLUCOSE-6-PHOSPHATE-DEHYDROGENASE ; REDOX HOMEOSTASIS ; BLADDER-CANCER ; G6PD ; EXPRESSION ; METABOLISM ; PROLIFERATION |
| 资助项目 | National Nature Science Foundation of China[81973356] ; National Nature Science Foundation of China[81902826] ; Fundamental Research Funds for the Central Universities, Nankai University[3206054] ; Fundamental Research Funds for the Central Universities, Nankai University[91923101] ; Fundamental Research Funds for the Central Universities, Nankai University[63213082] ; Fundamental Research Funds for the Central Universities, Nankai University[92122017] ; State Key Laboratory of Drug Research[SIMM2105KF-08] ; National Key R&D Program of China[2018YFC2002000] |
| WOS研究方向 | Life Sciences & Biomedicine - Other Topics ; Microbiology |
| 语种 | 英语 |
| WOS记录号 | WOS:000762280300001 |
| 出版者 | MDPI |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/300318]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Zhang, Shuai; Shan, Changliang |
| 作者单位 | 1.Nankai Univ, Coll Pharm, State Key Lab Med Chem Biol, Tianjin 300350, Peoples R China 2.Nankai Univ, Tianjin Key Lab Mol Drug Res, Tianjin 300350, Peoples R China 3.Tianjin Univ Tradit Chinese Med, Sch Integrat Med, Tianjin 301617, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China |
| 推荐引用方式 GB/T 7714 | Song, Jiaqi,Sun, Huanran,Zhang, Shuai,et al. The Multiple Roles of Glucose-6-Phosphate Dehydrogenase in Tumorigenesis and Cancer Chemoresistance[J]. LIFE-BASEL,2022,12(2):19. |
| APA | Song, Jiaqi,Sun, Huanran,Zhang, Shuai,&Shan, Changliang.(2022).The Multiple Roles of Glucose-6-Phosphate Dehydrogenase in Tumorigenesis and Cancer Chemoresistance.LIFE-BASEL,12(2),19. |
| MLA | Song, Jiaqi,et al."The Multiple Roles of Glucose-6-Phosphate Dehydrogenase in Tumorigenesis and Cancer Chemoresistance".LIFE-BASEL 12.2(2022):19. |
入库方式： OAI收割
来源：上海药物研究所
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