Versatile ginsenoside Rg3 liposomes inhibit tumor metastasis by capturing circulating tumor cells and destroying metastatic niches
文献类型：期刊论文
| 作者 | Xia, Jiaxuan3,4; Ma, Shaojie5,6; Zhu, Xi2,7; Chen, Chen3,4; Zhang, Ru3,4; Cao, Zhonglian3,4; Chen, Xing3,4; Zhang, Longlong3,4; Zhu, Ying3,4; Zhang, Shuya3,4 |
| 刊名 | SCIENCE ADVANCES
 |
| 出版日期 | 2022-02-01 |
| 卷号 | 8期号:6页码:19 |
| ISSN号 | 2375-2548 |
| DOI | 10.1126/sciadv.abj1262 |
| 通讯作者 | Wang, Jianxin(jxwang@fudan.edu.cn) |
| 英文摘要 | Limited circulating tumor cells (CTCs) capturing efficiency and lack of regulation capability on CTC-supportive metastatic niches (MNs) are two main obstacles hampering the clinical translation of conventional liposomes for the treatment of metastatic breast cancers. Traditional delivery strategies, such as ligand modification and immune modulator co-encapsulation for nanocarriers, are inefficient and laborious. Here, a multifunctional Rg3 liposome loading with docetaxel (Rg3-Lp/DTX) was developed, in which Rg3 was proved to intersperse in the phospholipid bilayer and exposed its glycosyl on the liposome surface. Therefore, it exhibited much higher CTC- capturing efficiency via interaction with glucose transporter 1 (Glut1) overexpressed on CTCs. After reaching the lungs with CTCs, Rg3 inhibited the formation of MNs by reversing the immunosuppressive microenvironment. Together, Rg3-Lp/DTX exhibited excellent metastasis inhibition capacity by CTC ("seeds") neutralization and MN ("soil") inhibition. The strategy has great clinical translation prospects for antimetastasis treatment with enhanced therapeutic efficacy and simple preparation process. |
| WOS关键词 | NF-KAPPA-B ; RESISTANT ; COMBINATION ; PACLITAXEL ; STRATEGIES ; THERAPY |
| 资助项目 | National Natural Science Foundation of China[82074277] ; National Natural Science Foundation of China[8177391] ; National Natural Science Foundation of China[81690263] ; Development Project of Shanghai Peak Disciplines-Integrated Medicine[20180101] ; National Key R&D Program of China[2020YFC0841400] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDPB2505] |
| WOS研究方向 | Science & Technology - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:000757383500003 |
| 出版者 | AMER ASSOC ADVANCEMENT SCIENCE |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/300333]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Wang, Jianxin |
| 作者单位 | 1.Fudan Univ, Inst Integrat Med, Shanghai 201203, Peoples R China 2.Shanghai Jiao Tong Univ, Sch Biomed Engn, Shanghai 200030, Peoples R China 3.Fudan Univ, Sch Pharm, Dept Pharmaceut, Shanghai 201203, Peoples R China 4.Minist Educ, Key Lab Smart Drug Delivery, Shanghai 201203, Peoples R China 5.Chinese Acad Sci, Drug Discovery & Design Ctr, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai 201203, Peoples R China 6.Huazhong Univ Sci & Technol, Coll Life Sci & Technol, Key Lab Mol Biophys, Minist Educ, Wuhan 430071, Peoples R China 7.Shanghai Jiao Tong Univ, Med X Res Inst, Shanghai Canc Inst, State Key Lab Oncogenes & Related Genes, Shanghai 200030, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xia, Jiaxuan,Ma, Shaojie,Zhu, Xi,et al. Versatile ginsenoside Rg3 liposomes inhibit tumor metastasis by capturing circulating tumor cells and destroying metastatic niches[J]. SCIENCE ADVANCES,2022,8(6):19. |
| APA | Xia, Jiaxuan.,Ma, Shaojie.,Zhu, Xi.,Chen, Chen.,Zhang, Ru.,...&Wang, Jianxin.(2022).Versatile ginsenoside Rg3 liposomes inhibit tumor metastasis by capturing circulating tumor cells and destroying metastatic niches.SCIENCE ADVANCES,8(6),19. |
| MLA | Xia, Jiaxuan,et al."Versatile ginsenoside Rg3 liposomes inhibit tumor metastasis by capturing circulating tumor cells and destroying metastatic niches".SCIENCE ADVANCES 8.6(2022):19. |
入库方式： OAI收割
来源：上海药物研究所
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