Mitochondria homeostasis: Biology and involvement in hepatic steatosis to NASH
文献类型：期刊论文
| 作者 | Li, Yu-feng1; Xie, Zhi-fu1; Song, Qian1,3; Li, Jing-ya1,2,3
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| 刊名 | ACTA PHARMACOLOGICA SINICA
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| 出版日期 | 2022-02-01 |
| 页码 | 15 |
| 关键词 | liver NASH mitochondria metabolism mitochondrial homeostasis |
| ISSN号 | 1671-4083 |
| DOI | 10.1038/s41401-022-00864-z |
| 通讯作者 | Li, Jing-ya(jyli@simm.ac.cn) |
| 英文摘要 | Mitochondrial biology and behavior are central to the physiology of liver. Multiple mitochondrial quality control mechanisms remodel mitochondrial homeostasis under physiological and pathological conditions. Mitochondrial dysfunction and damage induced by overnutrition lead to oxidative stress, inflammation, liver cell death, and collagen production, which advance hepatic steatosis to nonalcoholic steatohepatitis (NASH). Accumulating evidence suggests that specific interventions that target mitochondrial homeostasis, including energy metabolism, antioxidant effects, and mitochondrial quality control, have emerged as promising strategies for NASH treatment. However, clinical translation of these findings is challenging due to the complex and unclear mechanisms of mitochondrial homeostasis in the pathophysiology of NASH. |
| WOS关键词 | NONALCOHOLIC FATTY LIVER ; ACTIVATED RECEPTOR-ALPHA ; MESSENGER-RNA STABILITY ; NLRP3 INFLAMMASOME ACTIVATION ; OXIDATIVE STRESS ; LIPID-METABOLISM ; VITAMIN-E ; SUCCINATE-DEHYDROGENASE ; PROTEOLYTIC CLEAVAGE ; ENERGY-METABOLISM |
| 资助项目 | National Natural Science Foundation of China[92057116] ; National Natural Science Foundation of China[81673493] ; National Science and Technology Major Project[2018ZX09711002-018] ; Natural Science Foundation of Shanghai's 2021 Science and Technology Innovation Action Plan[21ZR1475300] ; China Postdoctoral Science Foundation[2021M703349] |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000749432500001 |
| 出版者 | NATURE PUBL GROUP |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/300336]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Li, Jing-ya |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 2.Univ Chinese Acad Sci, Hangzhou Inst Adv Study, Hangzhou 310024, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Yu-feng,Xie, Zhi-fu,Song, Qian,et al. Mitochondria homeostasis: Biology and involvement in hepatic steatosis to NASH[J]. ACTA PHARMACOLOGICA SINICA,2022:15. |
| APA | Li, Yu-feng,Xie, Zhi-fu,Song, Qian,&Li, Jing-ya.(2022).Mitochondria homeostasis: Biology and involvement in hepatic steatosis to NASH.ACTA PHARMACOLOGICA SINICA,15. |
| MLA | Li, Yu-feng,et al."Mitochondria homeostasis: Biology and involvement in hepatic steatosis to NASH".ACTA PHARMACOLOGICA SINICA (2022):15. |
入库方式： OAI收割
来源：上海药物研究所
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