Effects of Zuojin Pill (Rhizoma Coptidis and Fructus Evodiae preparation) on the pharmacokinetics and side effects of venlafaxine in humans
文献类型：期刊论文
| 作者 | Yan, Dongmin2; Wu, Ming1,3; Hu, Wenjuan4 ; Li, Yue2; Jin, Jingyi2; Yan, Shaoqing5; Zhu, Wei6; Ye, Chaoyang1,3; Liu, Jia4; Liu, Guobin5
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| 刊名 | BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY
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| 出版日期 | 2022-04-01 |
| 卷号 | 130期号:4页码:522-530 |
| 关键词 | human pharmacokinetics side effect venlafaxine Zuojin Pill |
| ISSN号 | 1742-7835 |
| DOI | 10.1111/bcpt.13713 |
| 通讯作者 | Liu, Guobin(drliuguobin@163.com) ; Tan, Bo(tbot@163.com) |
| 英文摘要 | Venlafaxine (VEN), a first-line antidepressant, and Zuojin Pill (ZJP), a common herbal medicine consisting of Rhizoma Coptidis and Fructus Evodiae, are high likely co-administered in China. ZJP could significantly inhibit VEN pharmacokinetics in vitro and in rats through suppression of CYP2D6 activity. To date, however, no clinical study has demonstrated the clinical relevance. Here, the VEN pharmacokinetics at a single dose of VEN with or without co-administration of ZJP was compared. ZJP had a weak herb-drug interactions (HDI) on the pharmacokinetics of VEN. The geometric means of C-max and AUC(0-infinity) of VEN increased by 36.7% and 34.6%, respectively, and the corresponding 90% confidence intervals (CIs) of geometric mean ratios (GMRs) exceed outside bioequivalent range of 0.80-1.25. However, the corresponding 90% CIs of GMRs of these parameters for ODV were within the range. Since ODV exposure (AUC), approximately 3.4-fold higher than that of VEN, hardly changed, the systemic exposure of VEN active moiety (VEN + ODV) with ZJP increased slightly (<= 8.5%) compared with that of VEN alone. In addition, the incidence of VEN-related side effects, especially gastrointestinal relevance, was significantly reduced with ZJP. Therefore, rational concomitant use of VEN and ZJP might have low risk of HDI and be promising in clinical practice. |
| WOS关键词 | CYP2C19 GENOTYPES ; DRUG-INTERACTIONS ; IN-VITRO ; CYP2D6 ; BERBERINE ; PLASMA ; RAT |
| 资助项目 | Shanghai Municipal Health Commission[201740199] ; Science and Technology Commission of Shanghai Municipality[21Y21920200] ; Shanghai University of Traditional Chinese Medicine[2021LK075] ; Shuguang Hospital Affiliated to Shanghai University of Traditional Chinese Medicine[SGXZ-201907] |
| WOS研究方向 | Pharmacology & Pharmacy ; Toxicology |
| 语种 | 英语 |
| WOS记录号 | WOS:000757962100001 |
| 出版者 | WILEY |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/300339]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Liu, Guobin; Tan, Bo |
| 作者单位 | 1.Shanghai Univ Tradit Chinese Med, Shanghai Key Lab Tradit Chinese Clin Med, Minist Educ, Key Lab Liver & Kidney Dis, Shanghai, Peoples R China 2.Shanghai Univ Tradit Chinese Med, Shuguang Hosp, Inst Clin Pharmacol, Lab Clin Pharmacokinet, Shanghai, Peoples R China 3.Shanghai Univ Tradit Chinese Med, Shuguang Hosp, Dept Nephrol, Shanghai, Peoples R China 4.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai, Peoples R China 5.Shanghai Univ Tradit Chinese Med, Shuguang Hosp, Peripheral Vasc Dis Dept, Shanghai, Peoples R China 6.Wuxi Yike Tradit Chinese Med Hosp, Dept Clin Pharm, Wuxi, Jiangsu, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yan, Dongmin,Wu, Ming,Hu, Wenjuan,et al. Effects of Zuojin Pill (Rhizoma Coptidis and Fructus Evodiae preparation) on the pharmacokinetics and side effects of venlafaxine in humans[J]. BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY,2022,130(4):522-530. |
| APA | Yan, Dongmin.,Wu, Ming.,Hu, Wenjuan.,Li, Yue.,Jin, Jingyi.,...&Tan, Bo.(2022).Effects of Zuojin Pill (Rhizoma Coptidis and Fructus Evodiae preparation) on the pharmacokinetics and side effects of venlafaxine in humans.BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY,130(4),522-530. |
| MLA | Yan, Dongmin,et al."Effects of Zuojin Pill (Rhizoma Coptidis and Fructus Evodiae preparation) on the pharmacokinetics and side effects of venlafaxine in humans".BASIC & CLINICAL PHARMACOLOGY & TOXICOLOGY 130.4(2022):522-530. |
入库方式： OAI收割
来源：上海药物研究所
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