A Rhein-Based Rh(III) Arene Complex with Anti-tumor Cell Proliferative Activity Inhibits RNA Demethylase FTO
文献类型：期刊论文
| 作者 | Liu, Lu2,3; Kong, Yaqiong2; He, Liang4; Wang, Xiuxiu1; Wang, Meng-Meng2; Xu, Hongjiao3; Yang, Cai-Guang3,5 ; Su, Zhi2; Zhao, Jing1; Mao, Zong-Wan4
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| 刊名 | CHINESE JOURNAL OF CHEMISTRY
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| 出版日期 | 2022-02-12 |
| 页码 | 9 |
| 关键词 | Rhodium mRNA Antiproliferation FTO m(6)A |
| ISSN号 | 1001-604X |
| DOI | 10.1002/cjoc.202100901 |
| 通讯作者 | Su, Zhi(zhisu@njnu.edu.cn) ; Zhao, Jing(jingzhao@nju.edu.cn) ; Mao, Zong-Wan(cesmzw@mail.sysu.edu.cn) ; Huang, Yue(huangyue@simm.ac.cn) ; Liu, Hong-Ke(liuhongke@njnu.edu.cn) |
| 英文摘要 | Comprehensive Summary Metallodrugs with fine-tuned coordination between metals and bioactive ligands can achieve cytotoxic effects in cancer therapy and have been considered as a new approach for drug design. However, it has yet to be elucidated whether these metallodrugs target epitranscriptomic proteins for gene expression regulation. This report describes a rhein-based Rh(III)-arene complex, Rh1, that exhibited promising antiproliferative effects in several tumor cell lines. Rh1 induced cell death through the autophagy, cell cycle arrest, and accumulation of intracellular reactive oxygen species (ROS). In addition, Rh1 upregulated the global N-6-methyladenosine (m(6)A) levels in A549 cells in the fat mass- and obesity-associated protein (FTO)-dependent manner. Collectively, the metal-based FTO inhibitor Rh1 effectively suppressed tumor cell proliferation and modulated the abundance of cellular m(6)A, highlighting the potential of metal-based agents to target and regulate epitranscriptomics for tumor suppression. |
| WOS关键词 | METAL-COMPLEXES ; ANTICANCER ; THERAPY |
| 资助项目 | NSFC[22077066] ; NSFC[21771109] ; NSFC[21778033] ; NSFC[21701195] ; NSFC[21837006] ; NSFC[21977052] ; NSFC[21907101] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000754190100001 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/300415]  |
| 专题 | 新药研究国家重点实验室 |
| 通讯作者 | Su, Zhi; Zhao, Jing; Mao, Zong-Wan; Huang, Yue; Liu, Hong-Ke |
| 作者单位 | 1.Nanjing Univ, Sch Chem & Chem Engn, Nanjing 210023, Jiangsu, Peoples R China 2.Nanjing Normal Univ, Sch Chem & Mat Sci, Nanjing 210023, Jiangsu, Peoples R China 3.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 4.Sun Yat Sen Univ, Sch Chem, Guangzhou 510275, Guangdong, Peoples R China 5.Univ Chinese Acad Sci, Hangzhou Inst Adv Study, Sch Pharmaceut Sci & Technol, Hangzhou 310024, Zhejiang, Peoples R China |
| 推荐引用方式 GB/T 7714 | Liu, Lu,Kong, Yaqiong,He, Liang,et al. A Rhein-Based Rh(III) Arene Complex with Anti-tumor Cell Proliferative Activity Inhibits RNA Demethylase FTO[J]. CHINESE JOURNAL OF CHEMISTRY,2022:9. |
| APA | Liu, Lu.,Kong, Yaqiong.,He, Liang.,Wang, Xiuxiu.,Wang, Meng-Meng.,...&Liu, Hong-Ke.(2022).A Rhein-Based Rh(III) Arene Complex with Anti-tumor Cell Proliferative Activity Inhibits RNA Demethylase FTO.CHINESE JOURNAL OF CHEMISTRY,9. |
| MLA | Liu, Lu,et al."A Rhein-Based Rh(III) Arene Complex with Anti-tumor Cell Proliferative Activity Inhibits RNA Demethylase FTO".CHINESE JOURNAL OF CHEMISTRY (2022):9. |
入库方式： OAI收割
来源：上海药物研究所
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