Effects of Salvianolic Acid B/ginsenoside Rg1 Combination Against Chronic Pulmonary Embolism Induced by Polystyrene Microspheres
文献类型：期刊论文
| 作者 | Bian, Huimiao1,2; Han, Na2; Wang, Linlin1; Wang, Xiaoyu1; Cho, Kenka3; Yin, Jun2; Jiang, Baohong1
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| 刊名 | FOLIA BIOLOGICA-KRAKOW
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| 出版日期 | 2021-12-01 |
| 卷号 | 69期号:4页码:189-198 |
| 关键词 | salvianolic acid B ginsenoside Rg1 pulmonary embolism polystyrene microspheres |
| ISSN号 | 0015-5497 |
| DOI | 10.3409/fb_69-4.20 |
| 通讯作者 | Yin, Jun(yinjun826@sina.com) ; Jiang, Baohong(jiangbh@simm.ac.cn) |
| 英文摘要 | Pulmonary embolism (PE) is the most life-threatening complication of venous thromboembolism, but few effective treatments have been discovered to attenuate chronic PE currently. In this study, we investigated the protective effects of salvianolic acid B (SalB) and ginsenoside Rg1 (Rg1) combination (SalB/Rg1) on chronic PE and explored the potential mechanisms. The PE model was induced by 45 im polystyrene microspheres and 20 mg/kg of SalB/ Rg1 was administered to PE rats intraperitoneally. A histopathological analysis of the lungs and heart was performed through hematoxylin and eosin staining and immunohistochemical analysis. The pulmonary index and right ventricular cardiomyocyte cross- sectional area were evaluated. SalB/ Rg1 markedly downregulated pulmonary index, attenuated pulmonary interstitial changes, suppressed neutrophil infiltration, prevented collagen deposition, and inhibited MMP- 9 activities in the lung. We also found that SalB/Rg1 improved right ventricular hypertrophy accompanied by reducing the cardiomyocyte cross-sectional area. These data suggest that SalB/Rg1 played a protective role against microsphere-induced PE and holds a high potential for the treatment of PE in the future. |
| WOS关键词 | GINSENOSIDE RG1 ; INJURY ; SAFETY |
| 资助项目 | Inter-governmental Science and Technology Innovation Cooperation Program, Ministry of Science and Technology of China[2021YFE0111300] ; National Natural Science Foundation of China[81770478] ; National Natural Science Foundation of China[81970395] ; Shanghai Science and Technology Development Foundation[21S21901900] ; Biological Resources Program, Chinese Academy of Sciences[KFJ-BRP-008-005] |
| WOS研究方向 | Life Sciences & Biomedicine - Other Topics |
| 语种 | 英语 |
| WOS记录号 | WOS:000755165400004 |
| 出版者 | POLISH ACAD SCIENCES, INST SYSTEMATICS EVOLUTION ANIMALS |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/300430]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Yin, Jun; Jiang, Baohong |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai, Peoples R China 2.Shenyang Pharmaceut Univ, Sch Tradit Chinese Mat, Shenyang, Peoples R China 3.Univ Med & Hlth Care, Takarazuka, Hyogo, Japan |
| 推荐引用方式 GB/T 7714 | Bian, Huimiao,Han, Na,Wang, Linlin,et al. Effects of Salvianolic Acid B/ginsenoside Rg1 Combination Against Chronic Pulmonary Embolism Induced by Polystyrene Microspheres[J]. FOLIA BIOLOGICA-KRAKOW,2021,69(4):189-198. |
| APA | Bian, Huimiao.,Han, Na.,Wang, Linlin.,Wang, Xiaoyu.,Cho, Kenka.,...&Jiang, Baohong.(2021).Effects of Salvianolic Acid B/ginsenoside Rg1 Combination Against Chronic Pulmonary Embolism Induced by Polystyrene Microspheres.FOLIA BIOLOGICA-KRAKOW,69(4),189-198. |
| MLA | Bian, Huimiao,et al."Effects of Salvianolic Acid B/ginsenoside Rg1 Combination Against Chronic Pulmonary Embolism Induced by Polystyrene Microspheres".FOLIA BIOLOGICA-KRAKOW 69.4(2021):189-198. |
入库方式： OAI收割
来源：上海药物研究所
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