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Light-controllable charge-reversal nanoparticles with polyinosinic-polycytidylic acid for enhancing immunotherapy of triple negative breast cancer

文献类型：期刊论文

作者Fang, Lei3,4,5; Zhao, Zitong4,5; Wang, Jue4,5; Xiao, Ping4,5; Sun, Xiangshi4,5; Ding, Yaping3; Zhang, Pengcheng2,4,5; Wang, Dangge1,2,4,5; Li, Yaping1,2,4,5
刊名ACTA PHARMACEUTICA SINICA B
出版日期2022
卷号12期号:1页码:353-363
关键词Nanoparticles Cancer immunotherapy Photodynamic therapy Polyinosinic-polycytidylic acid Triple negative breast cancer Charge-reversal Tumor microenvironment ROS-responsive
ISSN号2211-3835
DOI10.1016/j.apsb.2021.06.006
通讯作者Wang, Dangge(dgwang@simm.ac.cn) ; Li, Yaping(ypli@simm.ac.cn)
英文摘要Nucleic acid drugs are highly applicable for cancer immunotherapy with promising therapeutic effects, while targeting delivery of these drugs to disease lesions remains challenging. Cationic polymeric nanoparticles have paved the way for efficient delivery of nucleic acid drugs, and achieved stimuli-responsive disassembly in tumor microenvironment (TME). However, TME is highly heterogeneous between individuals, and most nanocarriers lack active-control over the release of loaded nucleic acid drugs, which will definitely reduce the therapeutic efficacy. Herein, we have developed a light-controllable charge-reversal nanoparticle (LCCN) with controlled release of polyinosinic-polycytidylic acid [Poly(I:C)] to treat triple negative breast cancer (TNBC) by enhanced photodynamic immunotherapy. The nanoparticles keep suitably positive charge for stable loading of Poly(I:C), while rapidly reverse to negative charge after near-infrared light irradiation to release Poly(I:C). LCCN-Poly(I:C) nanoparticles trigger effective phototoxicity and immunogenic cell death on 4T1 tumor cells, elevate antitumor immune responses and inhibit the growth of primary and abscopal 4T1 tumors in mice. The approach provides a promising strategy for controlled release of various nucleic acid-based immune modulators, which may enhance the efficacy of photodynamic immunotherapy against TNBC (C) 2022 Chinese Pharmaceutical Association and Institute of Materia Medica, Chinese Academy of Medical Sciences. Production and hosting by Elsevier B.V.
WOS关键词CYCLOPHOSPHAMIDE ; EPIRUBICIN ; DELIVERY ; BLOCKADE
资助项目National Natural Science Foundation of China[81903548] ; National Natural Science Foundation of China[81690265] ; National Natural Science Foundation of China[81803444] ; National Natural Science Foundation of China[81521005] ; National Natural Science Foundation of China[32070927] ; Youth Innovation Promotion Association of CAS[2019283] ; Strategic Priority Research Program of CAS[XDA12050307] ; Shandong Provincial Natural Science Foundation[ZR2019ZD25] ; International Partnership Program of CAS[153631KYSB20190013] ; Shanghai Sailing Program[19YF1457300]
WOS研究方向Pharmacology & Pharmacy
语种英语
WOS记录号WOS:000746960200002
出版者INST MATERIA MEDICA, CHINESE ACAD MEDICAL SCIENCES
源URL[http://119.78.100.183/handle/2S10ELR8/300504]  
专题新药研究国家重点实验室
通讯作者Wang, Dangge; Li, Yaping
作者单位1.Yantai Univ, Sch Pharm, Yantai 264005, Peoples R China
2.Yantai Inst Mat Med, Yantai Key Lab Nanomed & Adv Preparat, Yantai 264000, Peoples R China
3.Shanghai Univ, Coll Sci, Shanghai 200444, Peoples R China
4.Chinese Acad Sci, State Key Lab Drug Res, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
5.Chinese Acad Sci, Ctr Pharmaceut, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
推荐引用方式
GB/T 7714		 Fang, Lei,Zhao, Zitong,Wang, Jue,et al. Light-controllable charge-reversal nanoparticles with polyinosinic-polycytidylic acid for enhancing immunotherapy of triple negative breast cancer[J]. ACTA PHARMACEUTICA SINICA B,2022,12(1):353-363.
APA Fang, Lei.,Zhao, Zitong.,Wang, Jue.,Xiao, Ping.,Sun, Xiangshi.,...&Li, Yaping.(2022).Light-controllable charge-reversal nanoparticles with polyinosinic-polycytidylic acid for enhancing immunotherapy of triple negative breast cancer.ACTA PHARMACEUTICA SINICA B,12(1),353-363.
MLA Fang, Lei,et al."Light-controllable charge-reversal nanoparticles with polyinosinic-polycytidylic acid for enhancing immunotherapy of triple negative breast cancer".ACTA PHARMACEUTICA SINICA B 12.1(2022):353-363.

入库方式： OAI收割

来源：上海药物研究所

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