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Antidepressant-like effects of cinnamamide derivative M2 via D-2 receptors in the mouse medial prefrontal cortex

文献类型：期刊论文

作者Che, Yan-xin2; Jin, Xiao-yan2; Xiao, Rong-hua2; Zhang, Ming1,3; Ma, Xiao-hui4; Guo, Fei1,3; Li, Yang1,2,3
刊名ACTA PHARMACOLOGICA SINICA
出版日期2022-01-25
页码9
ISSN号1671-4083
关键词depression D-2 receptor medial prefrontal cortex pyramidal neurons mTOR TrkB
DOI10.1038/s41401-021-00854-7
通讯作者Guo, Fei(guofei@simm.ac.cn) ; Li, Yang(liyang@simm.ac.cn)
英文摘要Major depressive disorder is a global mental illness associated with severe mortality and disability. The dopaminergic system is involved in both the etiology and therapeutics of depression. Distinct functions of dopamine D-1 and D-2 receptor subtypes have attracted considerable research interest, and their roles in the pathogenesis of depression and interaction with antidepressants need to be comprehensively elucidated. Herein, we investigated the antidepressant effects of a candidate antidepressant from a cinnamamide derivative, M2, and examined underlying neural mechanisms. We observed that a single dose of M2 (30 mg/kg, ip) produced rapid antidepressant-like effects in mice subjected to the forced swim and tail suspension tests. Using whole-cell recordings in mouse coronal brain slices, we found that application of M2 (10-150 mu M) concentration-dependently increased the frequency of spontaneous excitatory postsynaptic currents (sEPSCs) of the pyramidal neurons in the medial prefrontal cortex (mPFC). Furthermore, M2-induced enhancement of sEPSC frequency was abolished by sulpiride (10 mu M), a dopamine D2 receptor antagonist, but not by the dopamine receptor D-1 antagonist, SCH23390 (10 mu M). In addition, M2 administration significantly increased expression levels of synaptogenesis-related proteins, including p-mTOR and p-TrkB, in the mPFC at 30 min, and increased postsynaptic protein PSD-95 at 24 h. Our results demonstrated that M2 produces rapid antidepressant actions through a novel mechanism via dopamine D-2 receptor-mediated enhancement of mPFC neurotransmission.
WOS关键词RAPID ANTIDEPRESSANT ; SYNAPTIC-TRANSMISSION ; DEPRESSION ; DOPAMINE ; MODULATION ; NEURONS ; STRESS ; RATS
资助项目Strategic Priority Research Program of the Chinese Academy of Sciences[XDA12040220] ; National Natural Science Foundation of China[31671049] ; National Natural Science Foundation of China[31371066] ; National Key New Drug Creation Program of China[2018ZX09711002-002-012] ; Shanghai Municipal Science and Technology Major Project ; Science and Technology Commission of Shanghai Municipality[184319071000] ; Science and Technology Commission of Shanghai Municipality[19140903102] ; Tasly Pharma, Inc.
WOS研究方向Chemistry ; Pharmacology & Pharmacy
语种英语
出版者NATURE PUBL GROUP
WOS记录号WOS:000746752300001
源URL[http://119.78.100.183/handle/2S10ELR8/300513]  
专题中国科学院上海药物研究所
通讯作者Guo, Fei; Li, Yang
作者单位1.Chinese Acad Sci, Ctr Neurol & Psychiat Res & Drug Discovery, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China
2.Nanjing Univ Chinese Med, Sch Chinese Mat Med, Nanjing 210023, Peoples R China
3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
4.Tasly Pharmaceut Grp Co Ltd, State Key Lab Core Technol Innovat Chinese Med, Tianjin 300410, Peoples R China
推荐引用方式
GB/T 7714		 Che, Yan-xin,Jin, Xiao-yan,Xiao, Rong-hua,et al. Antidepressant-like effects of cinnamamide derivative M2 via D-2 receptors in the mouse medial prefrontal cortex[J]. ACTA PHARMACOLOGICA SINICA,2022:9.
APA Che, Yan-xin.,Jin, Xiao-yan.,Xiao, Rong-hua.,Zhang, Ming.,Ma, Xiao-hui.,...&Li, Yang.(2022).Antidepressant-like effects of cinnamamide derivative M2 via D-2 receptors in the mouse medial prefrontal cortex.ACTA PHARMACOLOGICA SINICA,9.
MLA Che, Yan-xin,et al."Antidepressant-like effects of cinnamamide derivative M2 via D-2 receptors in the mouse medial prefrontal cortex".ACTA PHARMACOLOGICA SINICA (2022):9.

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来源：上海药物研究所

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