Berberine and its derivatives represent as the promising therapeutic agents for inflammatory disorders
文献类型：期刊论文
| 作者 | Lu, Qiukai1; Fu, Yifan2; Li, Heng1 |
| 刊名 | PHARMACOLOGICAL REPORTS
 |
| 出版日期 | 2022-01-27 |
| 页码 | 13 |
| 关键词 | Allergy Berberine Inflammation Ulcerative colitis |
| ISSN号 | 1734-1140 |
| DOI | 10.1007/s43440-021-00348-7 |
| 通讯作者 | Fu, Yifan(yifanfu@njmu.edu.cn) ; Li, Heng(cpuliheng@126.com) |
| 英文摘要 | Berberine, with the skeleton of quaternary ammonium, has been considered as the well-defined natural product in treating multiple diseases, including inflammation, acute and chronic infection, autoimmune diseases, and diabetes. However, due to the low bioavailability and systemic exposure, broad clinical applications of berberine have been largely impeded. Numerous studies have been conducted to further explore the therapeutic capacities of berberine in preclinical and clinical trials. Over the past, berberine and its derivatives have been shown to possess numerous pharmacological activities, as evidenced in intestinal, pulmonary, skin, and bone inflammatory disorders. In the present review, the pharmacological impact of berberine on inflammatory diseases are fully discussed, with indication that berberine and its potential derivatives represent promising natural therapeutic agents with anti-inflammatory properties. |
| WOS关键词 | INNATE LYMPHOID-CELLS ; TNBS-INDUCED COLITIS ; RHEUMATOID-ARTHRITIS ; MOLECULAR-MECHANISMS ; MULTIPLE-SCLEROSIS ; INTESTINAL BARRIER ; SIGNALING PATHWAY ; P-GLYCOPROTEIN ; BOWEL-DISEASE ; IN-VITRO |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000749077500001 |
| 出版者 | SPRINGER HEIDELBERG |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/300528]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Fu, Yifan; Li, Heng |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, 555 Zuchongzhi Rd, Shanghai 201203, Peoples R China 2.Nanjing Med Univ, Sch Pharm, Dept Med Chem, Nanjing 211166, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lu, Qiukai,Fu, Yifan,Li, Heng. Berberine and its derivatives represent as the promising therapeutic agents for inflammatory disorders[J]. PHARMACOLOGICAL REPORTS,2022:13. |
| APA | Lu, Qiukai,Fu, Yifan,&Li, Heng.(2022).Berberine and its derivatives represent as the promising therapeutic agents for inflammatory disorders.PHARMACOLOGICAL REPORTS,13. |
| MLA | Lu, Qiukai,et al."Berberine and its derivatives represent as the promising therapeutic agents for inflammatory disorders".PHARMACOLOGICAL REPORTS (2022):13. |
入库方式： OAI收割
来源：上海药物研究所
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