Structure genomics of SARS-CoV-2 and its Omicron variant: drug design templates for COVID-19
文献类型：期刊论文
| 作者 | Wu, Can-rong1; Yin, Wan-chao1; Jiang, Yi1 ; Xu, H. Eric1,2
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| 刊名 | ACTA PHARMACOLOGICA SINICA
 |
| 出版日期 | 2022-01-20 |
| 页码 | 13 |
| 关键词 | COVID-19 SARS-CoV-2 structural biology omicron drug design vaccine development |
| ISSN号 | 1671-4083 |
| DOI | 10.1038/s41401-021-00851-w |
| 通讯作者 | Wu, Can-rong(wucanrong@simm.ac.cn) ; Xu, H. Eric(eric.xu@simm.ac.cn) |
| 英文摘要 | Coronavirus disease 2019 (COVID-19), caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), has brought an unprecedented public health crisis and persistently threatens to humanity. With tireless efforts from scientists around the world, understanding of the biology of coronavirus has been greatly enhanced over the past 2 years. Structural biology has demonstrated its powerful impact on uncovering structures and functions for the vast majority of SARS-CoV-2 proteins and guided the development of drugs and vaccines against COVID-19. In this review, we summarize current progress in the structural biology of SARS-CoV-2 and discuss important biological issues that remain to be addressed. We present the examples of structure-based design of Pfizer's novel anti-SARS-CoV-2 drug PF-07321332 (Paxlovid), Merck's nucleotide inhibitor molnupiravir (Lagevrio), and VV116, an oral drug candidate for COVID-19. These examples highlight the importance of structure in drug discovery to combat COVID-19. We also discussed the recent variants of Omicron and its implication in immunity escape from existing vaccines and antibody therapies. |
| WOS关键词 | RESPIRATORY SYNDROME CORONAVIRUS ; CRYO-EM STRUCTURE ; NUCLEOCAPSID PROTEIN ; REPLICATION ; INHIBITORS ; REVEALS ; COMPLEX ; SPIKE ; POLYMERASE ; ANTIBODIES |
| 资助项目 | Ministry of Science and Technology (China)[2018YFA0507002] ; Shanghai Municipal Science and Technology Major Project[2019SHZDZX02] ; CAS Strategic Priority Research Program[XDB08020303] ; National Natural Science Foundation of China[31770796] ; Youth Innovation Promotion Association of CAS[2021278] |
| WOS研究方向 | Chemistry ; Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000744808000001 |
| 出版者 | NATURE PUBL GROUP |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/300562]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Wu, Can-rong; Xu, H. Eric |
| 作者单位 | 1.Chinese Acad Sci, Shanghai Inst Mat Med, CAS Key Lab Receptor Res, Shanghai 201203, Peoples R China 2.ShanghaiTech Univ, Sch Life Sci & Technol, Shanghai 201210, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wu, Can-rong,Yin, Wan-chao,Jiang, Yi,et al. Structure genomics of SARS-CoV-2 and its Omicron variant: drug design templates for COVID-19[J]. ACTA PHARMACOLOGICA SINICA,2022:13. |
| APA | Wu, Can-rong,Yin, Wan-chao,Jiang, Yi,&Xu, H. Eric.(2022).Structure genomics of SARS-CoV-2 and its Omicron variant: drug design templates for COVID-19.ACTA PHARMACOLOGICA SINICA,13. |
| MLA | Wu, Can-rong,et al."Structure genomics of SARS-CoV-2 and its Omicron variant: drug design templates for COVID-19".ACTA PHARMACOLOGICA SINICA (2022):13. |
入库方式： OAI收割
来源：上海药物研究所
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