Highly oxygenated isoryanodane diterpenoids from the leaves of Cinnamomum cassia and their immunomodulatory activities
文献类型：期刊论文
| 作者 | Zhou, Lei1; Zheng, Guijuan1; Li, Heng2; Gao, Biao1; Guoruoluo, Yindengzhi1; Tang, Wei2 ; Yao, Guangmin1,3; Zhang, Yonghui1
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| 刊名 | PHYTOCHEMISTRY
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| 出版日期 | 2022-04-01 |
| 卷号 | 196页码:10 |
| 关键词 | Cinnamomum cassia (L.) J. presl. (Lauraceae) Isoryanodane diterpenoids Single-crystal X-ray diffraction Calculated C-13 NMR-DP4+analysis Immunomodulatory activity |
| ISSN号 | 0031-9422 |
| DOI | 10.1016/j.phytochem.2021.113077 |
| 通讯作者 | Tang, Wei(tangwei@simm.ac.cn) ; Yao, Guangmin(gyap@mail.hust.edu.cn) ; Zhang, Yonghui(zhangyh@mails.tjmu.edu.cn) |
| 英文摘要 | A total of twelve highly oxygenated isoryanodane (also known as cinncassiol D-type) diterpenoids including nine undescribed ones, named cinnacassins A I, were isolated from the leaves of Cinnamomum cassia. Their chemical structures were elucidated by extensive spectrometric and spectroscopic techniques including HRESIMS, 1D and 2D NMR, single-crystal X-ray diffraction analysis, calculated C-13-NMR DP4+ analysis, and chemical methods. The absolute configuration of cinnacassin A was unambiguously delineated by single-crystal X-ray diffraction analysis. Cinnacassin H represents the first example of 16-O-glucosylated isoryanodane diterpenoid, and cinnacassin I is the first isoryanod-13(18)-ene diterpenoid. The relationship of the configuration C-18 and the chemical shifts of H2-19 and C-20 in the 19-hydroxy-isoryanodane diterpenoids was discussed, and the 18S-configuration of three known 19-hydroxy-isoryanodane diterpenoids, cinncassiol D1, 19-O-beta-D-glucopyranosylcinncassiol D1, and cinncassiol D3 was assigned. All the isolated isoryanodane diterpenoids were evaluated for their immunomodulatory effects in vitro, and cinnacassin A and cinncassiol D1 enhanced the proliferation of Con A-induced murine T cells with enhancement rates ranging from 17.9% to 45.4%, which were more potent than the positive control, thymosin alpha(1). In addition, cinncassiol D-1 significantly promoted the proliferation of LPSinduced murine B cells with an enhancement rate up to 116.1%, two-fold more potent than thymosin a1 at a concentration of 1.5625 mu M. |
| WOS关键词 | CINNCASSIOL D1 ; CONSTITUENTS ; CORTEX ; BARKS ; TWIGS ; GLUCOSIDE ; BUDS |
| 资助项目 | Open Project of State Key Laboratory of Chemistry and Molecular Engineering of Medicinal Resources[CMEMR-2021-B03] ; Scientific research project of traditional Chinese medicine of Hubei Provincial Health Commission[ZY 2021M056] ; National Natural Science Foundation of China[U1703109] ; National Natural Science Foundation of China[31370372] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Plant Sciences |
| 语种 | 英语 |
| WOS记录号 | WOS:000743319100007 |
| 出版者 | PERGAMON-ELSEVIER SCIENCE LTD |
| 源URL | [http://119.78.100.183/handle/2S10ELR8/300571]  |
| 专题 | 中国科学院上海药物研究所 |
| 通讯作者 | Tang, Wei; Yao, Guangmin; Zhang, Yonghui |
| 作者单位 | 1.Huazhong Univ Sci & Technol, Sch Pharm, Hubei Key Lab Nat Med Chem & Resource Evaluat, Wuhan 430030, Hubei, Peoples R China 2.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China 3.Guangxi Normal Univ, State Key Lab Chem & Mol Engn Med Resources, Guilin 541004, Peoples R China |
| 推荐引用方式 GB/T 7714 | Zhou, Lei,Zheng, Guijuan,Li, Heng,et al. Highly oxygenated isoryanodane diterpenoids from the leaves of Cinnamomum cassia and their immunomodulatory activities[J]. PHYTOCHEMISTRY,2022,196:10. |
| APA | Zhou, Lei.,Zheng, Guijuan.,Li, Heng.,Gao, Biao.,Guoruoluo, Yindengzhi.,...&Zhang, Yonghui.(2022).Highly oxygenated isoryanodane diterpenoids from the leaves of Cinnamomum cassia and their immunomodulatory activities.PHYTOCHEMISTRY,196,10. |
| MLA | Zhou, Lei,et al."Highly oxygenated isoryanodane diterpenoids from the leaves of Cinnamomum cassia and their immunomodulatory activities".PHYTOCHEMISTRY 196(2022):10. |
入库方式： OAI收割
来源：上海药物研究所
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