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Efficient synthesis of monophosphoryl lipid A mimetic RC-529

文献类型：期刊论文

作者Zhou, Chengkai1,2; Xu, Zhuojia1,3; Li, Gen4; Gao, Qi4; Sui, Qiang2,4; Li, Tiehai1
刊名JOURNAL OF CARBOHYDRATE CHEMISTRY
出版日期2021-12-27
页码17
关键词Glycolipid synthesis adjuvant lipid A RC-529
ISSN号0732-8303
DOI10.1080/07328303.2021.2016793
通讯作者Li, Tiehai(tiehaili@simm.ac.cn)
英文摘要An efficient approach for the facile synthesis of a potent vaccine adjuvant RC-529 is described. The synthetic strategy relies on the flexible use of orthogonal protecting groups, which makes it possible to accomplish selective phosphorylation, glycosylation and acylation, respectively. In addition, the use of readily cleaved 2-naphthylmethyl (Nap) ether and allyl esters as permanent protecting groups greatly facilitates the final global deprotection steps to obtain pure RC-529. This work will contribute to the synthesis of lipid A and its derivatives.
WOS关键词BIOLOGICAL EVALUATION ; ADJUVANTS ; ENDOTOXIN ; REAGENT ; MILD ; TOLL
资助项目National Natural Science Foundation of China[22077130] ; Shanghai Pujiang Program[20PJ1415800] ; Science and Technology Commission of Shanghai Municipality[20ZR1467900] ; Shanghai Municipal Science and Technology Major Project ; National Major Scientific and Technological Special Project for Significant New Drugs Development[2019ZX09302014]
WOS研究方向Biochemistry & Molecular Biology ; Chemistry
语种英语
WOS记录号WOS:000736013000001
出版者TAYLOR & FRANCIS INC
源URL[http://119.78.100.183/handle/2S10ELR8/300652]  
专题中国科学院上海药物研究所
通讯作者Li, Tiehai
作者单位1.Chinese Acad Sci, Shanghai Inst Mat Med, Shanghai 201203, Peoples R China
2.Shanghai Univ Engn Sci, Shanghai, Peoples R China
3.Univ Chinese Acad Sci, Beijing, Peoples R China
4.China State Inst Pharmaceut Ind, Shanghai, Peoples R China
推荐引用方式
GB/T 7714		 Zhou, Chengkai,Xu, Zhuojia,Li, Gen,et al. Efficient synthesis of monophosphoryl lipid A mimetic RC-529[J]. JOURNAL OF CARBOHYDRATE CHEMISTRY,2021:17.
APA Zhou, Chengkai,Xu, Zhuojia,Li, Gen,Gao, Qi,Sui, Qiang,&Li, Tiehai.(2021).Efficient synthesis of monophosphoryl lipid A mimetic RC-529.JOURNAL OF CARBOHYDRATE CHEMISTRY,17.
MLA Zhou, Chengkai,et al."Efficient synthesis of monophosphoryl lipid A mimetic RC-529".JOURNAL OF CARBOHYDRATE CHEMISTRY (2021):17.

入库方式： OAI收割

来源：上海药物研究所

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