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Dietary alcohol exacerbates the hepatotoxicity induced by pyrrolizidine alkaloids: Hazard from food contamination

文献类型：期刊论文

作者He, Yisheng1; Long, Yun1; Zhang, Chunyuan1; Ma, Jiang1; Ke, Changqiang2; Tang, Chunping2; Ye, Yang2; Lin, Ge1
刊名JOURNAL OF HAZARDOUS MATERIALS
出版日期2022-02-15
卷号424页码:12
ISSN号0304-3894
关键词food contamination pyrrolizidine alkaloids alcohol dietary exposure mead
DOI10.1016/j.jhazmat.2021.127706
通讯作者Lin, Ge(linge@cuhk.edu.hk)
英文摘要Pyrrolizidine alkaloids (PAs) are the most common plant-derived toxins with emerging evidence to contaminate soil, water, nearby plants and derived food products. Outbreaks of human poisoning cases, due to the ingestion of PA-contaminated food, have been reported in various countries including Ethiopia. This study first investigated the contamination of PAs in retail honey in Ethiopia. A striking 77% of honey samples (27/30) were found to contain PAs with the content ranging over 1.5-323.4 mu g/kg. Notably, these PAs were also found as contaminants in mead, an alcoholic beverage made from local honey, indicating the transfer of PAs from the primarily contaminated honey into mead. Further toxicological examinations revealed that long-term PA exposure caused vasculature damage, fibrosis, and steatosis in mouse livers, and co-exposure to dietary alcohol exacerbated the PA-induced chronic hepatotoxicity. Furthermore, the study revealed that moderate alcohol intake did not affect the initiation mechanism (hepatic cytochrome P450-mediated bioactivation) of PA-induced hepatotoxicity but significantly disturbed hepatic glutathione homeostasis, thereby increasing oxidative stress in mouse liver and enhancing PA-induced hepatotoxicity. Our findings exemplify the carry-over of PA contamination through the food chain. Precautionary interventions are warranted on the hazardous effects of dietary exposure to PAs, particularly with concomitant alcohol consumption.
WOS关键词SINUSOIDAL ENDOTHELIAL-CELLS ; LIVER-DISEASE ; VENOOCCLUSIVE DISEASE ; MASS-SPECTROMETRY ; FIRM EVIDENCE ; GLUTATHIONE ; HONEY ; METABOLISM ; RISK ; MECHANISMS
资助项目Research Grants Council of Hong Kong Special Administrative Region[14110714] ; Research Grants Council of Hong Kong Special Administrative Region[14106318]
WOS研究方向Engineering ; Environmental Sciences & Ecology
语种英语
出版者ELSEVIER
WOS记录号WOS:000734373800004
源URL[http://119.78.100.183/handle/2S10ELR8/300664]  
专题新药研究国家重点实验室
通讯作者Lin, Ge
作者单位1.Chinese Univ Hong Kong, Fac Med, Sch Biomed Sci, Hong Kong, Peoples R China
2.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, Shanghai, Peoples R China
推荐引用方式
GB/T 7714		 He, Yisheng,Long, Yun,Zhang, Chunyuan,et al. Dietary alcohol exacerbates the hepatotoxicity induced by pyrrolizidine alkaloids: Hazard from food contamination[J]. JOURNAL OF HAZARDOUS MATERIALS,2022,424:12.
APA He, Yisheng.,Long, Yun.,Zhang, Chunyuan.,Ma, Jiang.,Ke, Changqiang.,...&Lin, Ge.(2022).Dietary alcohol exacerbates the hepatotoxicity induced by pyrrolizidine alkaloids: Hazard from food contamination.JOURNAL OF HAZARDOUS MATERIALS,424,12.
MLA He, Yisheng,et al."Dietary alcohol exacerbates the hepatotoxicity induced by pyrrolizidine alkaloids: Hazard from food contamination".JOURNAL OF HAZARDOUS MATERIALS 424(2022):12.

入库方式： OAI收割

来源：上海药物研究所

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