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One uncommon bis-sesquiterpenoid from Xisha soft coral Litophyton nigrum

文献类型：期刊论文

作者Yang, Fan1,2,3,4; Hua, Qiang1,2; Yao, Li-Gong3; Liang, Lin-Fu5; Lou, Yu-Xia4; Lu, Yan-Hua1,2; An, Fa-Liang1,2; Guo, Yue-Wei3
刊名TETRAHEDRON LETTERS
出版日期2022-01-05
卷号88页码:4
关键词Litophyton nigrum Soft coral Bis-sesquiterpenoid Nardosinane
ISSN号0040-4039
DOI10.1016/j.tetlet.2021.153571
通讯作者An, Fa-Liang(flan2016@ecust.edu.cn) ; Guo, Yue-Wei(ywguo@simm.ac.cn)
英文摘要One uncommon sesquiterpenoid dimer (1), a new nardosinane-type sesquiterpenoid (3), along with two known sesquiterpenoids (2 and 4) were isolated from soft coral Litophyton nigrum using a structure-oriented HR-MS/MS approach. The configurations of the isolates were determined by spectroscopic data analyses, including HR-ESI-MS, 1D/2D NMR, single crystal X-ray diffraction, and DP4+ statistical analyses. Compound 3 exhibited potent PTP1B inhibitory activity (IC50 = 10.67 +/- 1.81 mu g/mL) compared to the positive control. (C) 2021 Elsevier Ltd. All rights reserved.
WOS关键词SKELETON
资助项目National Key Research and Development Program of China[2018YFC0310903] ; National Natural Science Foundation of China[81991521] ; National Natural Science Foundation of China[41876194]
WOS研究方向Chemistry
语种英语
WOS记录号WOS:000740353300024
出版者PERGAMON-ELSEVIER SCIENCE LTD
源URL[http://119.78.100.183/handle/2S10ELR8/300679]  
专题新药研究国家重点实验室
通讯作者An, Fa-Liang; Guo, Yue-Wei
作者单位1.Shanghai Collaborat Innovat Ctr Biomfg Technol, 130 Meilong Rd, Shanghai 200237, Peoples R China
2.East China Univ Sci & Technol, State Key Lab Bioreactor Engn, 130 Meilong Rd, Shanghai 200237, Peoples R China
3.Chinese Acad Sci, Shanghai Inst Mat Med, State Key Lab Drug Res, 555 Chong Zhi Rd,Zhangjiang Hitech Pk, Shanghai 201203, Peoples R China
4.Shanghai Normal Univ, Coll Life Sci, 100 Guilin Rd, Shanghai 200234, Peoples R China
5.Cent South Univ Forestry & Technol, Coll Mat Sci & Engn, 498 South Shaoshan Rd, Changsha 410004, Peoples R China
推荐引用方式
GB/T 7714		 Yang, Fan,Hua, Qiang,Yao, Li-Gong,et al. One uncommon bis-sesquiterpenoid from Xisha soft coral Litophyton nigrum[J]. TETRAHEDRON LETTERS,2022,88:4.
APA Yang, Fan.,Hua, Qiang.,Yao, Li-Gong.,Liang, Lin-Fu.,Lou, Yu-Xia.,...&Guo, Yue-Wei.(2022).One uncommon bis-sesquiterpenoid from Xisha soft coral Litophyton nigrum.TETRAHEDRON LETTERS,88,4.
MLA Yang, Fan,et al."One uncommon bis-sesquiterpenoid from Xisha soft coral Litophyton nigrum".TETRAHEDRON LETTERS 88(2022):4.

入库方式： OAI收割

来源：上海药物研究所

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