A biological functional hybrid scaffold based on decellularized extracellular matrix/gelatin/chitosan with high biocompatibility and antibacterial activity for skin tissue engineering
文献类型：期刊论文
| 作者 | Xu, Jie1; Fang, Huan1; Zheng, Shuangshuang2; Li, Liying1; Jiao, Zeren3; Wang, Hong4; Nie, Yi2,5; Liu, Tianqing1; Song, Kedong1 |
| 刊名 | INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES
 |
| 出版日期 | 2021-09-30 |
| 卷号 | 187页码:840-849 |
| ISSN号 | 0141-8130 |
| 关键词 | Antibacterial Skin tissue engineering Decellularized extracellular matrix |
| DOI | 10.1016/j.ijbiomac.2021.07.162 |
| 英文摘要 | Nowadays, decellularized extracellular matrix (dECM) has received widespread attention due to its diversity in providing the unique structural and functional components to support cell growth, and finding material with good biocompatibility and anti-infection capability for skin tissue engineering is still a challenge. In this study, a novel dECM/Gel/CS scaffold with appropriate mechanical strength, good antibacterial activity and high biocompatibility was prepared using a one-pot method. The results showed that the immune components such as cells and DNA (about 98.1%) were successfully removed from the porcine skin tissue. The dECM/Gel/CS scaf-folds exhibited an interconnected pore structure and had a high porosity (>90%) to promote cell growth. Moreover, the appropriate elastic modulus (>482.17 kPa) and degradability (>80.04% for 15 days) of the scaffolds offered stout "houses" for cell proliferation and suitable degradation rate to match the new tissue formation in skin tissue engineering. Furthermore, the addition of chitosan endowed the scaffold with good antibacterial activity, water and protein absorption capacity to avoid wound infection, and maintain the mois-ture and nutrition balance. In vitro cytocompatibility studies showed that the presence of dECM effectively enhanced the cell proliferation. Overall, the advanced dECM/Gel/CS scaffold has considerable potential to be applied in skin tissue engineering. |
| WOS关键词 | MATRIX BIOINK ; MECHANICAL-PROPERTIES ; NANOFIBROUS MATS ; HYDROGEL ; CONSTRUCTS ; THERAPY |
| 资助项目 | National Natural Science Foundation of China[31670978/21676041] ; Fok Ying Tung Education Foun-dation[132027] ; State Key Laboratory of Fire Science[KF1111] ; Natural Science Foundation of Liaoning[20180510028] ; Fundamental Research Funds for the Central Universities[DUT20ZD206/DUT20YG118/DUT21YG113] |
| WOS研究方向 | Biochemistry & Molecular Biology ; Chemistry ; Polymer Science |
| 语种 | 英语 |
| 出版者 | ELSEVIER |
| WOS记录号 | WOS:000691784600003 |
| 资助机构 | National Natural Science Foundation of China ; Fok Ying Tung Education Foun-dation ; State Key Laboratory of Fire Science ; Natural Science Foundation of Liaoning ; Fundamental Research Funds for the Central Universities |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/50097]  |
| 专题 | 中国科学院过程工程研究所 |
| 通讯作者 | Wang, Hong; Nie, Yi; Liu, Tianqing; Song, Kedong |
| 作者单位 | 1.Dalian Univ Technol, Dalian R&D Ctr Stem Cell & Tissue Engn, State Key Lab Fine Chem, Dalian 116024, Peoples R China 2.Zhengzhou Inst Emerging Ind Technol, Zhengzhou 450000, Peoples R China 3.Texas A&M Univ, Artie McFerrin Dept Chem Engn, College Stn, TX 77843 USA 4.Dalian Med Univ, Dept Orthopead, Dalian Municipal Cent Hosp, Dalian 116033, Peoples R China 5.Chinese Acad Sci, Inst Proc Engn, Key Lab Green Proc & Engn, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xu, Jie,Fang, Huan,Zheng, Shuangshuang,et al. A biological functional hybrid scaffold based on decellularized extracellular matrix/gelatin/chitosan with high biocompatibility and antibacterial activity for skin tissue engineering[J]. INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,2021,187:840-849. |
| APA | Xu, Jie.,Fang, Huan.,Zheng, Shuangshuang.,Li, Liying.,Jiao, Zeren.,...&Song, Kedong.(2021).A biological functional hybrid scaffold based on decellularized extracellular matrix/gelatin/chitosan with high biocompatibility and antibacterial activity for skin tissue engineering.INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES,187,840-849. |
| MLA | Xu, Jie,et al."A biological functional hybrid scaffold based on decellularized extracellular matrix/gelatin/chitosan with high biocompatibility and antibacterial activity for skin tissue engineering".INTERNATIONAL JOURNAL OF BIOLOGICAL MACROMOLECULES 187(2021):840-849. |
入库方式： OAI收割
来源：过程工程研究所
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