Enhancing therapeutic performance of personalized cancer vaccine via delivery vectors
文献类型：期刊论文
| 作者 | Ye, Tong1,2; Li, Feng1,2; Ma, Guanghui1,2; Wei, Wei1,2 |
| 刊名 | ADVANCED DRUG DELIVERY REVIEWS
 |
| 出版日期 | 2021-10-01 |
| 卷号 | 177页码:23 |
| 关键词 | Neoantigen Whole cancer cell vaccine Immunogenic cell death Liposome Polymer Microorganism Delivery strategy DC vaccine Precise medicine |
| ISSN号 | 0169-409X |
| DOI | 10.1016/j.addr.2021.113927 |
| 英文摘要 | In recent years, personalized cancer vaccines have gained increasing attention as emerging immunother-apies with the capability to overcome interindividual differences and show great benefits for individual patients in the clinic due to the highly tailored vaccine formulations. A large number of materials have been studied as delivery vectors to enhance the therapeutic performance of personalized cancer vaccines, including artificial materials, engineered microorganisms, cells and cell derivatives. These delivery vec-tors with distinct features are employed to change antigen biodistributions and to facilitate antigen uptake, processing and presentation, improving the strength, velocity, and duration of the immune response when delivered by different strategies. Here, we provide an overview of personalized cancer vaccine delivery vectors, describing their materials, physicochemical properties, delivery strategies and challenges for clinical transformation. (c) 2021 Elsevier B.V. All rights reserved. |
| WOS关键词 | IMMUNOGENIC CELL-DEATH ; IMMUNE CHECKPOINT BLOCKADE ; DENDRITIC CELLS ; NANOPARTICLE VACCINES ; GRAPHENE OXIDE ; DRUG-DELIVERY ; LYMPH-NODE ; IN-VIVO ; TUMOR MICROENVIRONMENT ; ANTIGEN TRAFFICKING |
| 资助项目 | National Natural Science Foundation of China[U2001224] ; National Natural Science Foundation of China[32030062] ; National Natural Science Foundation of China[21821005] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB29040303] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000704290900008 |
| 出版者 | ELSEVIER |
| 资助机构 | National Natural Science Foundation of China ; Strategic Priority Research Program of the Chinese Academy of Sciences |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/50500]  |
| 专题 | 中国科学院过程工程研究所 |
| 通讯作者 | Wei, Wei |
| 作者单位 | 1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Sch Chem Engn, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ye, Tong,Li, Feng,Ma, Guanghui,et al. Enhancing therapeutic performance of personalized cancer vaccine via delivery vectors[J]. ADVANCED DRUG DELIVERY REVIEWS,2021,177:23. |
| APA | Ye, Tong,Li, Feng,Ma, Guanghui,&Wei, Wei.(2021).Enhancing therapeutic performance of personalized cancer vaccine via delivery vectors.ADVANCED DRUG DELIVERY REVIEWS,177,23. |
| MLA | Ye, Tong,et al."Enhancing therapeutic performance of personalized cancer vaccine via delivery vectors".ADVANCED DRUG DELIVERY REVIEWS 177(2021):23. |
入库方式： OAI收割
来源：过程工程研究所
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