Advances in Functionalized Carriers Based on Graphene's Unique Biological Interface Effect
文献类型：期刊论文
| 作者 | Yue, Hua1; Ma, Guanghui1,2 |
| 刊名 | ACTA CHIMICA SINICA
 |
| 出版日期 | 2021-10-15 |
| 卷号 | 79期号:10页码:1244-1256 |
| 关键词 | graphene biological interface effect 2D carrier drug delivery vaccine adjuvant |
| ISSN号 | 0567-7351 |
| DOI | 10.6023/A21050238 |
| 英文摘要 | The interaction of two-dimensional graphene and its derivatives with biological interfaces exhibits distinct properties and advantages over traditional dimensional particles, offering potential strategies for the design and development of functionalized pharmaceutical carriers. Apart from the excellent electrical, thermal and optical properties, the two-dimensional structure endows the graphene stronger interactions with cell membranes and then induces obvious cellular response. These responses include the horizontal friction/slant insertion or sandwiched superstructure, selective internalization by phagocytes, folding effect upon the limited intracellular space, autophagy phenomenon and invisible activation. Based on these unique interfacial effects and theoretical simulation mechanisms, rational designs will meet the needs of drug delivery, vaccine carriers, imaging and sensing, and photothermal therapy as well as good biosafety. This review concludes our researches of exploring the biological interface effects, dynamic molecular mechanism, and applications regarding graphene (oxide) in the past 10 years. Meanwhile, it also covers the latest international progress, in order to provide theoretical basis and prospective prediction for the design, construction, and application of efficient and safe graphene systems. |
| WOS关键词 | GENE DELIVERY ; QUANTUM DOTS ; OXIDE ; CYTOTOXICITY ; SIZE ; NANOPARTICLES ; FLUORESCENCE ; MECHANISMS ; MEMBRANES ; ADJUVANT |
| 资助项目 | Beijing Municipal Natural Science Foundation[2202056] ; Key Program of National Natural Science Foundation of China[32030062] |
| WOS研究方向 | Chemistry |
| 语种 | 英语 |
| WOS记录号 | WOS:000708054800005 |
| 出版者 | SCIENCE PRESS |
| 资助机构 | Beijing Municipal Natural Science Foundation ; Key Program of National Natural Science Foundation of China |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/50607]  |
| 专题 | 中国科学院过程工程研究所 |
| 通讯作者 | Ma, Guanghui |
| 作者单位 | 1.Chinese Acad Sci, Inst Proc Engn, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yue, Hua,Ma, Guanghui. Advances in Functionalized Carriers Based on Graphene's Unique Biological Interface Effect[J]. ACTA CHIMICA SINICA,2021,79(10):1244-1256. |
| APA | Yue, Hua,&Ma, Guanghui.(2021).Advances in Functionalized Carriers Based on Graphene's Unique Biological Interface Effect.ACTA CHIMICA SINICA,79(10),1244-1256. |
| MLA | Yue, Hua,et al."Advances in Functionalized Carriers Based on Graphene's Unique Biological Interface Effect".ACTA CHIMICA SINICA 79.10(2021):1244-1256. |
入库方式： OAI收割
来源：过程工程研究所
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