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Self-Catalytic Small Interfering RNA Nanocarriers for Synergistic Treatment of Neurodegenerative Diseases

文献类型：期刊论文

作者Ji, Weihong1,2; Li, Yan3; Peng, Huan1,2; Zhao, Ruichen1,2; Shen, Jie1,2; Wu, Yanyue1,2; Wang, Jianze1; Hao, Qiulian1; Lu, Zhiguo1; Yang, Jun1
刊名ADVANCED MATERIALS
出版日期2021-10-23
页码13
ISSN号0935-9648
关键词brain delivery nanozymes neurodegenerative diseases self-catalysis siRNA synergistic treatment
DOI10.1002/adma.202105711
英文摘要Gene therapy has shown great potential for neurodegenerative diseases with complex pathology. However, its therapeutic effect is limited due to the delivery barriers and its own single function. Herein, self-catalytic small interfering RNA (siRNA) nanocarriers (S/Ce-PABMS) are developed to catalyze delivery process and treatment process for synergistic treatment of neurodegenerative diseases. On the one hand, the rough surface of the S/Ce-PABMS mediated by ceria (CeO2) nanozymes can catalyze cellular uptake in the delivery process, so that S/Ce-PABMS with acetylcholine analogs penetrate the blood-brain barrier and enter neurons more effectively. On the other hand, the CeO2 nanozymes can catalyze the treatment process by scavenging excess reactive oxygen species, and cooperate with siRNA-targeting SNCA to decrease the alpha-synuclein (alpha-syn) aggregation and alleviate the Parkinsonian pathology. Moreover, the S/Ce-PABMS treatment reduces the number of activated microglia and regulates the release of inflammatory cytokine, thereby relieving neuroinflammation. After treatment with S/Ce-PABMS, dyskinesia in Parkinson's disease model mice is significantly alleviated. The finding shows that the self-catalytic nanocarriers, S/Ce-PABMS, have great potential in the treatment of neurodegenerative diseases.
WOS关键词BLOOD-BRAIN-BARRIER ; MITOCHONDRIAL DYSFUNCTION ; OXIDATIVE STRESS ; SIRNA DELIVERY ; GENE-THERAPY ; NANOPARTICLES ; VIRUS ; INFECTIONS
资助项目National Natural Science Foundation of China[21875254] ; National Natural Science Foundation of China[21905283] ; National Natural Science Foundation of China[31771095] ; National Natural Science Foundation of China[32071391] ; National Natural Science Foundation of China[52073287] ; National Natural Science Foundation of China[22075289] ; Beijing Natural Science Foundation[2192057] ; Beijing Nova Program[Z201100006820140]
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics
语种英语
出版者WILEY-V C H VERLAG GMBH
WOS记录号WOS:000710090800001
资助机构National Natural Science Foundation of China ; Beijing Natural Science Foundation ; Beijing Nova Program
源URL[http://ir.ipe.ac.cn/handle/122111/50650]  
专题中国科学院过程工程研究所
通讯作者Zhang, Xin
作者单位1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Sch Chem Engn, Beijing 100049, Peoples R China
3.Univ Sci & Technol Beijing, Sch Chem & Biol Engn, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714		 Ji, Weihong,Li, Yan,Peng, Huan,et al. Self-Catalytic Small Interfering RNA Nanocarriers for Synergistic Treatment of Neurodegenerative Diseases[J]. ADVANCED MATERIALS,2021:13.
APA Ji, Weihong.,Li, Yan.,Peng, Huan.,Zhao, Ruichen.,Shen, Jie.,...&Zhang, Xin.(2021).Self-Catalytic Small Interfering RNA Nanocarriers for Synergistic Treatment of Neurodegenerative Diseases.ADVANCED MATERIALS,13.
MLA Ji, Weihong,et al."Self-Catalytic Small Interfering RNA Nanocarriers for Synergistic Treatment of Neurodegenerative Diseases".ADVANCED MATERIALS (2021):13.

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来源：过程工程研究所

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