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Efficacy of Dual-Targeting Combined Anti-Tuberculosis Drug Delivery System in the Treatment of Tuberculous Meningitis

文献类型：期刊论文

作者Ma, Wenjing1,2,7; Peng, Huan3,4; Liu, Kewei5; Wang, Yaguo1,7; Wang, Wei5; Qu, Shilin6; Li, Yan3; Bi, Lijun1,7; Zhang, Xin3; Zhang, Liqun5
刊名JOURNAL OF BIOMEDICAL NANOTECHNOLOGY
出版日期2021-10-01
卷号17期号:10页码:2034-2042
ISSN号1550-7033
关键词Tuberculous Meningitis Cell Penetrating Peptide Blood-Brain Barrier Macrophages Drug Delivery System
DOI10.1166/jbn.2021.3169
英文摘要Tuberculous meningitis (TBM) is an incurable disease with high morality. It is an xtrapulmonary tuberculosis caused by Copyr ght: American Scientific Publ shers mycobacterium tuberculosis which penetrated theblood-brain barrier and infected the meninges. Mycobacterium tuberDelivered by Ingenta culosis lurking in the body mainly reside in macrophages. Anti-tuberculous drugs usually can not target the blood-brain barrier and macrophages, the drug concentration in the lesion is low, which cannot effectively kill mycobacterium tuberculosis, making TBM difficult to treat. Targeted drug delivery systems can target drugs to specific nidus. In the study, we constructed a drug delivery system, which was a cell penetrate peptide B6 and phosphatidylserine (PS) modified polyethylene glycol (PEG) nanomaterial to target the blood-brain barrier and to target macrophages. This nanomaterial was a combined anti-tuberculosis drug delivery system encapsulating antituberculosis drugs rifampicin and pyrazinamide, designed to target macrophages in the brain and kill mycobacterium tuberculosis lurking in the macrophages. We have physically characterized the drug delivery system, and verified the bactericidal ability at cellular and animal level. Results have shown that the targeted drug delivery system had a remarkable efficacy to treat TBM in mice.
WOS关键词BRAIN ; PHOSPHATIDYLSERINE ; NANOPARTICLES ; LYMPHOCYTES
资助项目Ministry of Science and Technology, People's Republic of China[2018ZX10302302001009] ; Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support[ZYLX201824] ; Beijing Municipal Administration of Hospitals' Ascent Plan[DFL20181602]
WOS研究方向Science & Technology - Other Topics ; Materials Science
语种英语
出版者AMER SCIENTIFIC PUBLISHERS
WOS记录号WOS:000712817400001
资助机构Ministry of Science and Technology, People's Republic of China ; Beijing Municipal Administration of Hospitals Clinical Medicine Development of Special Funding Support ; Beijing Municipal Administration of Hospitals' Ascent Plan
源URL[http://ir.ipe.ac.cn/handle/122111/50912]  
专题中国科学院过程工程研究所
通讯作者Zhang, Xin; Zhang, Liqun
作者单位1.Chinese Acad Sci, Ctr Excellence Biomacromol, Inst Biophys, Natl Lab Biomacromol, Beijing 100101, Peoples R China
2.South China Agr Univ, Coll Life Sci, Guangdong Prov Key Lab Prot Funct & Regulat Agr O, Guangzhou 510642, Guangdong, Peoples R China
3.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
4.Univ Chinese Acad Sci, Beijing 100049, Peoples R China
5.Capital Med Univ, Beijing Chest Hosp, Beijing TB & Thorac Tumor Res Inst, Beijing 101149, Peoples R China
6.Chest Hosp Jingzhou City, Jingzhou 434100, Hubei, Peoples R China
7.Chinese Acad Sci, Ctr Excellence Biomacromol, Inst Biophys, Key Lab Ribonucle Acid Biol, Beijing 100101, Peoples R China
推荐引用方式
GB/T 7714		 Ma, Wenjing,Peng, Huan,Liu, Kewei,et al. Efficacy of Dual-Targeting Combined Anti-Tuberculosis Drug Delivery System in the Treatment of Tuberculous Meningitis[J]. JOURNAL OF BIOMEDICAL NANOTECHNOLOGY,2021,17(10):2034-2042.
APA Ma, Wenjing.,Peng, Huan.,Liu, Kewei.,Wang, Yaguo.,Wang, Wei.,...&Zhang, Liqun.(2021).Efficacy of Dual-Targeting Combined Anti-Tuberculosis Drug Delivery System in the Treatment of Tuberculous Meningitis.JOURNAL OF BIOMEDICAL NANOTECHNOLOGY,17(10),2034-2042.
MLA Ma, Wenjing,et al."Efficacy of Dual-Targeting Combined Anti-Tuberculosis Drug Delivery System in the Treatment of Tuberculous Meningitis".JOURNAL OF BIOMEDICAL NANOTECHNOLOGY 17.10(2021):2034-2042.

入库方式： OAI收割

来源：过程工程研究所

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