Modelling of oligodextran production via an immobilized enzyme membrane reactor: Bioreaction-separation coupling mechanism
文献类型：期刊论文
| 作者 | Li, Xianhui1,2,3; Su, Ziran2; Luo, Yusen; Chen, Xueming4; Luo, Jianquan5; Pinelo, Manuel2 |
| 刊名 | SEPARATION AND PURIFICATION TECHNOLOGY
 |
| 出版日期 | 2022-02-01 |
| 卷号 | 282页码:12 |
| ISSN号 | 1383-5866 |
| 关键词 | Enzymatic membrane reactors (EMR) Modelling Immobilized enzymes Oligodextran Transport phenomena |
| DOI | 10.1016/j.seppur.2021.120024 |
| 英文摘要 | Use of immobilized enzymatic membrane reactors (EMR) is an effective strategy to enhance oligodextran production efficiency. Nevertheless, the reaction-separation coupling mechanism has not been fully understood. In this study, we developed a model to disentangle the mechanism and interaction behind the reaction and separation phenomena in the immobilized EMR to eventually evaluate process performance for optimal oligodextran production. The simulation results show that in the immobilized EMR applying substrate feeding mode and high operating pressure enhances convective and diffusive flows through membrane, leading to a high transport rate of product. The optimal substrate concentration and enzyme loading amount need to match the selectivity and permeability of the membrane, in order to ensure rapid removal of the target oligodextrans. Therefore, the membranes with high permselectivity are required for obtaining desirable production efficiency and product quality. Although immobilized EMR has higher reaction rate at the beginning because of higher local enzyme concentration in the reaction zone, the EMR with free enzymes could outperform the immobilized EMR by using higher enzyme concentration due to its larger reaction area as the reaction continues. Our study provides deep insights into the reaction-separation coupling mechanism and EMR performance enhancement. |
| WOS关键词 | ULTRAFILTRATION MEMBRANES ; FILTRATION ; DEXTRANASE ; LAYER |
| 资助项目 | European Union[713683] ; Program for Guangdong Introducing Innovative and Entrepreneurial Teams[2019ZT08L213] ; Key Special Project for Introduced Talents Team of Southern Marine Science and Engineering Guangdong Labo-ratory (Guangzhou)[GML2019ZD0403] |
| WOS研究方向 | Engineering |
| 语种 | 英语 |
| 出版者 | ELSEVIER |
| WOS记录号 | WOS:000722629100002 |
| 资助机构 | European Union ; Program for Guangdong Introducing Innovative and Entrepreneurial Teams ; Key Special Project for Introduced Talents Team of Southern Marine Science and Engineering Guangdong Labo-ratory (Guangzhou) |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/51193]  |
| 专题 | 中国科学院过程工程研究所 |
| 通讯作者 | Luo, Jianquan; Pinelo, Manuel |
| 作者单位 | 1.Guangdong Univ Technol, Inst Environm & Ecol Engn, Key Lab City Cluster Environm Safety & Green Dev, Minist Educ, Guangzhou 510006, Peoples R China 2.Tech Univ Denmark, Dept Chem & Biochem Engn, Proc & Syst Engn Ctr, DK-2800 Lyngby, Denmark 3.Southern Marine Sci & Engn Guangdong Lab Guangzho, Guangzhou 511458, Peoples R China 4.Fuzhou Univ, Coll Environm & Resources, Fujian 350116, Peoples R China 5.Univ Chinese Acad Sci, Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Li, Xianhui,Su, Ziran,Luo, Yusen,et al. Modelling of oligodextran production via an immobilized enzyme membrane reactor: Bioreaction-separation coupling mechanism[J]. SEPARATION AND PURIFICATION TECHNOLOGY,2022,282:12. |
| APA | Li, Xianhui,Su, Ziran,Luo, Yusen,Chen, Xueming,Luo, Jianquan,&Pinelo, Manuel.(2022).Modelling of oligodextran production via an immobilized enzyme membrane reactor: Bioreaction-separation coupling mechanism.SEPARATION AND PURIFICATION TECHNOLOGY,282,12. |
| MLA | Li, Xianhui,et al."Modelling of oligodextran production via an immobilized enzyme membrane reactor: Bioreaction-separation coupling mechanism".SEPARATION AND PURIFICATION TECHNOLOGY 282(2022):12. |
入库方式： OAI收割
来源：过程工程研究所
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