Nature-inspired dynamic gene-loaded nanoassemblies for the treatment of brain diseases
文献类型：期刊论文
| 作者 | Ji, Weihong1,3; Li, Yan1,2; Peng, Huan1,3; Zhao, Ruichen1,3; Zhang, Xin1 |
| 刊名 | ADVANCED DRUG DELIVERY REVIEWS
 |
| 出版日期 | 2022 |
| 卷号 | 180页码:24 |
| 关键词 | Nature-inspired Nanoassemblies Drug delivery systems Delivery barriers Gene therapy Brain disease Pathological microenvironment Stimuli-responsive |
| ISSN号 | 0169-409X |
| DOI | 10.1016/j.addr.2021.114029 |
| 英文摘要 | Gene therapy has great potential to treat brain diseases. However, genetic drugs need to overcome a cascade of barriers for their full potential. The conventional delivery systems often struggle to meet expectations. Natural biological particles that are highly optimized for specific functions in body, can inspire optimization of dynamic gene-loaded nanoassemblies (DGN). The DGN refer to gene loaded nanoassemblies whose functions and structures are changeable in response to the biological microenvironments or can dynamically interact with tissues or cells. The nature-inspired DGN can meet the needs in brain diseases treatment, including i) Non-elimination in blood (N), ii) Across the blood-brain barrier (A), iii) Targeting cells (T), iv) Efficient uptake (U), v) Controllable release (R), vi) Eyeable (E)-abbreviated as the "NATURE". In this Review, from nature to "NATURE", we mainly summarize the specific application of nature-inspired DGN in the "NATURE" cascade process. Furthermore, the Review provides an outlook for this field. (c) 2021 Elsevier B.V. All rights reserved. |
| WOS关键词 | STIMULI-RESPONSIVE NANOCARRIERS ; CELL-PENETRATING PEPTIDES ; SMALL INTERFERING RNA ; MEMBRANE-CAMOUFLAGED NANOPARTICLES ; DRUG-DELIVERY SYSTEM ; GOLD NANOPARTICLES ; ENDOSOMAL ESCAPE ; CONTRAST AGENTS ; SIRNA DELIVERY ; IN-VITRO |
| 资助项目 | Beijing Natural Science[2192057] ; National High Technology Research and Development Program[2016YFA0200303] ; National Natural Science of China[32071391] ; National Natural Science of China[52073287] ; National Natural Science of China[22075289] ; National Natural Science of China[21905283] ; National Natural Science of China[31771095] ; National Natural Science of China[21875254] ; Beijing Nova Program[Z201100006820140] |
| WOS研究方向 | Pharmacology & Pharmacy |
| 语种 | 英语 |
| WOS记录号 | WOS:000723581900002 |
| 出版者 | ELSEVIER |
| 资助机构 | Beijing Natural Science ; National High Technology Research and Development Program ; National Natural Science of China ; Beijing Nova Program |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/51228]  |
| 专题 | 中国科学院过程工程研究所 |
| 通讯作者 | Zhang, Xin |
| 作者单位 | 1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China 2.Univ Sci & Technol Beijing, Sch Chem & Biol Engn, Beijing 100083, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China |
| 推荐引用方式 GB/T 7714 | Ji, Weihong,Li, Yan,Peng, Huan,et al. Nature-inspired dynamic gene-loaded nanoassemblies for the treatment of brain diseases[J]. ADVANCED DRUG DELIVERY REVIEWS,2022,180:24. |
| APA | Ji, Weihong,Li, Yan,Peng, Huan,Zhao, Ruichen,&Zhang, Xin.(2022).Nature-inspired dynamic gene-loaded nanoassemblies for the treatment of brain diseases.ADVANCED DRUG DELIVERY REVIEWS,180,24. |
| MLA | Ji, Weihong,et al."Nature-inspired dynamic gene-loaded nanoassemblies for the treatment of brain diseases".ADVANCED DRUG DELIVERY REVIEWS 180(2022):24. |
入库方式： OAI收割
来源：过程工程研究所
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