Shielding Ferritin with a Biomineralized Shell Enables Efficient Modulation of Tumor Microenvironment and Targeted Delivery of Diverse Therapeutic Agents
文献类型：期刊论文
| 作者 | Wang, Changlong1,2; Wang, Xiaojun3; Zhang, Wei4,5,6; Ma, Ding4,5,6; Li, Feng1,2; Jia, Rongrong7; Shi, Min7; Wang, Yugang7; Ma, Guanghui1,2; Wei, Wei1,2 |
| 刊名 | ADVANCED MATERIALS
 |
| 出版日期 | 2021-12-13 |
| 页码 | 16 |
| 关键词 | biomineralization ferritin synergistic therapy tumor microenvironment |
| ISSN号 | 0935-9648 |
| DOI | 10.1002/adma.202107150 |
| 英文摘要 | Ferritin (Fn) is considered a promising carrier for targeted delivery to tumors, but the successful application in vivo has not been fully achieved yet. Herein, strong evidence is provided that the Fn receptor is expressed in liver tissues, resulting in an intercept effect in regards to tumor delivery. Building on these observations, a biomineralization technology is rationally designed to shield Fn using a calcium phosphate (CaP) shell, which can improve the delivery performance by reducing Fn interception in the liver while re-exposing it in acidic tumors. Moreover, the selective dissolution of the CaP shell not only neutralizes the acidic microenvironment but also induces the intratumoral immunomodulation and calcification. Upon multiple cell line and patient-derived xenografts, it is demonstrated that the elaboration of the highly flexible Fn@CaP chassis by loading a chemotherapeutic drug into the Fn cavity confers potent antitumor effects, and additionally encapsulating a photosensitizer into the outer shell enables a combined chemo-photothermal therapy for complete suppression of advanced tumors. Altogether, these results support Fn@CaP as a new nanoplatform for efficient modulation of the tumor microenvironment and targeted delivery of diverse therapeutic agents. |
| WOS关键词 | HUMAN SERUM-ALBUMIN ; CALCIUM-PHOSPHATE ; H-FERRITIN ; NANOPARTICLES ; MAGNETOFERRITIN ; BINDING ; BRAIN ; LIVER |
| 资助项目 | National Natural Science Foundation of China[U2001224] ; National Natural Science Foundation of China[21821005] ; National Natural Science Foundation of China[32030062] ; National Natural Science Foundation of China[21725301] ; National Natural Science Foundation of China[21821004] |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science ; Physics |
| 语种 | 英语 |
| WOS记录号 | WOS:000729432900001 |
| 出版者 | WILEY-V C H VERLAG GMBH |
| 资助机构 | National Natural Science Foundation of China |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/51346]  |
| 专题 | 中国科学院过程工程研究所 |
| 通讯作者 | Wei, Wei |
| 作者单位 | 1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Sch Chem Engn, Beijing 100049, Peoples R China 3.Shenzhen Univ, Affiliated Hosp 1, Shenzhen Peoples Hosp 2, Dept Neurosurg, Shenzhen 518039, Peoples R China 4.Peking Univ, Coll Chem & Mol Engn, Beijing Natl Lab Mol Engn, Beijing 100871, Peoples R China 5.Peking Univ, Coll Engn, Beijing 100871, Peoples R China 6.Peking Univ, BIC ESAT, Beijing 100871, Peoples R China 7.Shanghai Jiao Tong Univ, Sch Med, Tongren Hosp, Dept Gastroenterol, Shanghai 200336, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wang, Changlong,Wang, Xiaojun,Zhang, Wei,et al. Shielding Ferritin with a Biomineralized Shell Enables Efficient Modulation of Tumor Microenvironment and Targeted Delivery of Diverse Therapeutic Agents[J]. ADVANCED MATERIALS,2021:16. |
| APA | Wang, Changlong.,Wang, Xiaojun.,Zhang, Wei.,Ma, Ding.,Li, Feng.,...&Wei, Wei.(2021).Shielding Ferritin with a Biomineralized Shell Enables Efficient Modulation of Tumor Microenvironment and Targeted Delivery of Diverse Therapeutic Agents.ADVANCED MATERIALS,16. |
| MLA | Wang, Changlong,et al."Shielding Ferritin with a Biomineralized Shell Enables Efficient Modulation of Tumor Microenvironment and Targeted Delivery of Diverse Therapeutic Agents".ADVANCED MATERIALS (2021):16. |
入库方式： OAI收割
来源：过程工程研究所
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