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Kinetics and population balance modeling of antisolvent crystallization of polymorphic indomethacin

文献类型：期刊论文

作者Yang, Li1,2; Zhang, Yan1; Liu, Peng1,2; Wang, Chongqing1,3; Qu, Yanli1,2; Cheng, Jingcai1,4; Yang, Chao1,2
刊名CHEMICAL ENGINEERING JOURNAL
出版日期2022-01-15
卷号428页码:14
关键词Antisolvent crystallization Kinetics modeling Indomethacin Population balance equation Polymorph control
ISSN号1385-8947
DOI10.1016/j.cej.2021.132591
英文摘要This work focuses on an important problem that is the modeling and control of polymorphic crystallization of indomethacin (IMC) in which one of the crystal forms consists of hair-like crystals. The lack of kinetic knowledge impedes the seeking for methods of efficient polymorph control of IMC. Herein, kinetics of antisolvent crystallization of alpha-IMC and gamma-IMC were first time determined on the basis of experiments and the population balance equation (PBE). It was found that gamma-IMC has an advantage in the secondary nucleation rate. A higher temperature was more unfavorable for obtaining gamma-IMC under the same supersaturation because the gamma-IMC was at a disadvantage in both primary nucleation and growth rates. According to the results of population balance modeling, the primary nucleation rate of gamma-IMC only affected the polymorphic composition at the early stage of antisolvent crystallization. The growth rate of alpha-IMC is the key in effectively controlling the polymorph outcome.
WOS关键词CRYSTAL SIZE DISTRIBUTION ; PRECIPITATION ; NUCLEATION ; GROWTH ; TRANSFORMATION ; OPTIMIZATION ; AGGREGATION ; SIMULATION
资助项目National Natural Science Foundation of China[21938009] ; National Natural Science Foundation of China[21776284] ; National Natural Science Foundation of China[21878294] ; National Natural Science Foundation of China[22078332] ; National Key Research and Development Program[2019YFC1904204] ; NSFC-EU project[31961133018] ; External Cooperation Program of BIC, Chinese Academy of Sciences[122111KYSB20190032] ; Chemistry and Chemical Engineering Guangdong Laboratory[1922006]
WOS研究方向Engineering
语种英语
WOS记录号WOS:000729474600007
出版者ELSEVIER SCIENCE SA
资助机构National Natural Science Foundation of China ; National Key Research and Development Program ; NSFC-EU project ; External Cooperation Program of BIC, Chinese Academy of Sciences ; Chemistry and Chemical Engineering Guangdong Laboratory
源URL[http://ir.ipe.ac.cn/handle/122111/51415]  
专题中国科学院过程工程研究所
通讯作者Cheng, Jingcai
作者单位1.Chinese Acad Sci, Inst Proc Engn, CAS Key Lab Green Proc & Engn, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Sch Chem Engn, Beijing 100049, Peoples R China
3.Tianjin Univ, Sch Chem Engn & Technol, Tianjin 300072, Peoples R China
4.Chinese Acad Sci, Innovat Acad Green Manufacture, Beijing 100190, Peoples R China
推荐引用方式
GB/T 7714		 Yang, Li,Zhang, Yan,Liu, Peng,et al. Kinetics and population balance modeling of antisolvent crystallization of polymorphic indomethacin[J]. CHEMICAL ENGINEERING JOURNAL,2022,428:14.
APA Yang, Li.,Zhang, Yan.,Liu, Peng.,Wang, Chongqing.,Qu, Yanli.,...&Yang, Chao.(2022).Kinetics and population balance modeling of antisolvent crystallization of polymorphic indomethacin.CHEMICAL ENGINEERING JOURNAL,428,14.
MLA Yang, Li,et al."Kinetics and population balance modeling of antisolvent crystallization of polymorphic indomethacin".CHEMICAL ENGINEERING JOURNAL 428(2022):14.

入库方式： OAI收割

来源：过程工程研究所

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