Preparation of novel ropivacaine hydrochloride-loaded PLGA microspheres based on post-loading mode and efficacy evaluation
文献类型：期刊论文
| 作者 | Wen, Kang1,2; Na, Xiangming1,2; Yuan, Miaomiao2,3; Bazybek, Nardana1,2; Li, Xun1,2; Wei, Yi2 ; Ma, Guanghui1,2
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| 刊名 | COLLOIDS AND SURFACES B-BIOINTERFACES
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| 出版日期 | 2022-02-01 |
| 卷号 | 210页码:8 |
| 关键词 | ropivacaine hydrochloride microspheres self-healing sciatic nerve blockade model |
| ISSN号 | 0927-7765 |
| DOI | 10.1016/j.colsurfb.2021.112215 |
| 英文摘要 | Low encapsulation efficiency of the drug usually exist in hydrophilic drug which was embedded by hydrophobic materials directly in traditional method. In order to solve this problem, a novel preparation strategy which called "post-loading mode" was innovatively designed in this study: ropivacaine hydrochloride (ROP), a hydrophilic drug used in the field of anesthesia and analgesia, was encapsulated into the pre-prepared porous Poly (lactic-coglycolic acid) (PLGA) microspheres; the porous PLGA microspheres (PLGA-Ms) with self-healing characteristic were used to obtain ROP-PLGA-Ms (with particle size around were 38 mu m), in which drug loading (DL) was 8.72%. A rat sciatic nerve block model was established to evaluate the efficacy of ROP-PLGA-Ms. Exparel (R), a bupivacaine liposome suspension approved by the FDA, was defined as reference agents in this study. The results showed that the injection of ROP, Exparel (R), and ROP-PLGA-Ms were injected to the peripheral sciatic nerve could lead to motor dysfunction and sensory nerve block unanimously, and the onset time was less than 10 min for all cases. In addition, in comparison with ROP injection and Exparel (R), the nerve block time of ROP-PLGA-Ms was significantly prolonged (P < 0.05). Effective analgesia duration of ROP-PLGA-Ms was about 5 h, 2.5 and 1.7 folds longer than that of ROP injection and Exparel (R), respectively. The rats in each group could recover eventually within 8 h after administration. H&E showed that no inflammatory reaction was observed at the injection location. Analysis of blood biochemistry showed an insignificant difference between the microsphere experimental group and the negative group, which further indicated the safety of microsphere bioformulation. |
| WOS关键词 | SELF-HEALING ENCAPSULATION ; DRUG-DELIVERY SYSTEMS ; LOCAL-ANESTHETICS ; RELEASE ; DEXMEDETOMIDINE ; BUPIVACAINE ; BLOCK |
| 资助项目 | National Key Technology Program[2017ZX09201004014] |
| WOS研究方向 | Biophysics ; Chemistry ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000734889800001 |
| 出版者 | ELSEVIER |
| 资助机构 | National Key Technology Program |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/51546]  |
| 专题 | 中国科学院过程工程研究所 |
| 通讯作者 | Wei, Yi; Ma, Guanghui |
| 作者单位 | 1.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 2.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China 3.Wuhan Inst Technol, Wuhan 430205, Peoples R China |
| 推荐引用方式 GB/T 7714 | Wen, Kang,Na, Xiangming,Yuan, Miaomiao,et al. Preparation of novel ropivacaine hydrochloride-loaded PLGA microspheres based on post-loading mode and efficacy evaluation[J]. COLLOIDS AND SURFACES B-BIOINTERFACES,2022,210:8. |
| APA | Wen, Kang.,Na, Xiangming.,Yuan, Miaomiao.,Bazybek, Nardana.,Li, Xun.,...&Ma, Guanghui.(2022).Preparation of novel ropivacaine hydrochloride-loaded PLGA microspheres based on post-loading mode and efficacy evaluation.COLLOIDS AND SURFACES B-BIOINTERFACES,210,8. |
| MLA | Wen, Kang,et al."Preparation of novel ropivacaine hydrochloride-loaded PLGA microspheres based on post-loading mode and efficacy evaluation".COLLOIDS AND SURFACES B-BIOINTERFACES 210(2022):8. |
入库方式： OAI收割
来源：过程工程研究所
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