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p Recent advances in platelet engineering for anti-cancer therapies

文献类型：期刊论文

作者Lv, Yanlin1; Wei, Wei1,2; Ma, Guanghui1,2
刊名PARTICUOLOGY
出版日期2022-05-01
卷号64页码:2-13
ISSN号1674-2001
关键词Engineering platelets Platelet-mimicking Drug delivery Anti-cancer therapy
DOI10.1016/j.partic.2021.09.006
英文摘要Platelets contribute a major role in hemostasis by clumping and coagulation at the site of blood vessel injuries. In light of recent findings of a close relationship between platelets and immunological response, as well as interactions between platelets and cancer cells, novel engineering strategies have emerged for the integration of platelets or platelet membrane (PM) with anti-cancer therapeutics. In this review, we discuss several recent innovations that use platelets or their membranes to circumvent host immune responses and target tumor cells with high specificity to deliver a range of pharmacological, photothermal, or immunologic agents for eradication of recalcitrant tumor cells. More specifically, we compare the relative advantages of using whole platelets versus single or hybrid PM to coat nanoparticle cargoes. These cargoes range from well-established anti-tumor apoptosis-inducing agents, to relatively new photothermal agents that can induce a feedback cascade in which they induce vascular damage to the tumor which recruits more platelet-or membrane-encapsulated agents to induce further damage. We also discuss the use of engineered platelets to produce programmed cell death-inducing platelet derived microparticles. This review provides an overview and future directions for this promising platelet-based biomimetic approach to anti-cancer therapy. (c) 2021 Chinese Society of Particuology and Institute of Process Engineering, Chinese Academy of Sciences. Published by Elsevier B.V. This is an open access article under the CC BY-NC-ND license (http://creativecommons.org/licenses/by-nc-nd/4.0/).
WOS关键词DRUG-DELIVERY ; MEMBRANE ; NANOPARTICLES ; THROMBOSIS ; TUMORS ; CELLS
资助项目National Natural Science Foundation of China[21821005] ; National Natural Science Foundation of China[21907096] ; National Natural Science Foundation of China[82072406] ; National Key R&D Program of China[2017YFA0207900] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDB29040303]
WOS研究方向Engineering ; Materials Science
语种英语
出版者ELSEVIER SCIENCE INC
WOS记录号WOS:000743069300002
资助机构National Natural Science Foundation of China ; National Key R&D Program of China ; Strategic Priority Research Program of the Chinese Academy of Sciences
源URL[http://ir.ipe.ac.cn/handle/122111/51669]  
专题中国科学院过程工程研究所
通讯作者Ma, Guanghui
作者单位1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
2.Univ Chinese Acad Sci, Sch Chem Engn, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714		 Lv, Yanlin,Wei, Wei,Ma, Guanghui. p Recent advances in platelet engineering for anti-cancer therapies[J]. PARTICUOLOGY,2022,64:2-13.
APA Lv, Yanlin,Wei, Wei,&Ma, Guanghui.(2022).p Recent advances in platelet engineering for anti-cancer therapies.PARTICUOLOGY,64,2-13.
MLA Lv, Yanlin,et al."p Recent advances in platelet engineering for anti-cancer therapies".PARTICUOLOGY 64(2022):2-13.

入库方式： OAI收割

来源：过程工程研究所

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