Optimising the oil phases of aluminium hydrogel-stabilised emulsions for stable, safe and efficient vaccine adjuvant
文献类型：期刊论文
| 作者 | Yuan, Lili1; Gao, Xiao-Dong1; Xia, Yufei2,3,4 |
| 刊名 | FRONTIERS OF CHEMICAL SCIENCE AND ENGINEERING
 |
| 出版日期 | 2022-01-17 |
| 页码 | 12 |
| 关键词 | pickering emulsion vaccine adjuvant alum-stabilised emulsion oleic to linoleic acid ratio stability |
| ISSN号 | 2095-0179 |
| DOI | 10.1007/s11705-021-2123-1 |
| 英文摘要 | To increase antibody secretion and dose sparing, squalene-in-water aluminium hydrogel (alum)stabilised emulsions (ASEs) have been developed, which offer increased surface areas and cellular interactions for higher antigen loading and enhanced immune responses. Nevertheless, the squalene (oil) in previous attempts suffered from limited oxidation resistance, thus, safety and stability were compromised. From a clinical translational perspective, it is imperative to screen the optimal oils for enhanced emulsion adjuvants. Here, because of the varying oleic to linoleic acid ratio, soybean oil, peanut oil, and olive oil were utilised as oil phases in the preparation of aluminium hydrogel-stabilised squalene-in-water emulsions, which were then screened for their stability and immunogenicity. Additionally, the underlying mechanisms of oil phases and emulsion stability were unravelled, which showed that a higher oleic to linoleic acid ratio increased anti-oxidative capabilities but reduced the long-term storage stability owing to the relatively low zeta potential of the prepared droplets. As a result, compared with squalene-in-water ASEs, soybean-in-water ASEs exhibited comparable immune responses and enhanced stability. By optimising the oil phase of the emulsion adjuvants, this work may offer an alternative strategy for safe, stable, and effective emulsion adjuvants. |
| WOS关键词 | LIKERT SCALE ; QUALITY |
| 资助项目 | Beijing Nova Program of Beijing Municipal Science & Technology Commission[Z201100006820139] ; CAS Project for Young Scientists in Basic Research[YSBR-010] ; Pilot Project of Chinese Academy of Sciences[XDB29040303] ; Foundation for Innovative Research Groups of the National Natural Science Foundation of China[21821005] ; "From 0 to 1" Original Innovation Project of Basic Frontier Scientific Research Program of Chinese Academy of Sciences[2020000071] ; Youth Project of National Natural Science Foundation of China[21908229] ; Youth Innovation Promotion Association of the Chinese Academy of Sciences[2020000053] |
| WOS研究方向 | Engineering |
| 语种 | 英语 |
| WOS记录号 | WOS:000743413000002 |
| 出版者 | SPRINGER |
| 资助机构 | Beijing Nova Program of Beijing Municipal Science & Technology Commission ; CAS Project for Young Scientists in Basic Research ; Pilot Project of Chinese Academy of Sciences ; Foundation for Innovative Research Groups of the National Natural Science Foundation of China ; "From 0 to 1" Original Innovation Project of Basic Frontier Scientific Research Program of Chinese Academy of Sciences ; Youth Project of National Natural Science Foundation of China ; Youth Innovation Promotion Association of the Chinese Academy of Sciences |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/51718]  |
| 专题 | 中国科学院过程工程研究所 |
| 通讯作者 | Gao, Xiao-Dong; Xia, Yufei |
| 作者单位 | 1.Jiangnan Univ, Sch Biotechnol, Key Lab Carbohydrate Chem & Biotechnol, Minist Educ, Wuxi 214122, Jiangsu, Peoples R China 2.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China 3.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 4.Chinese Acad Sci, Innovat Acad Green Manufacture, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Yuan, Lili,Gao, Xiao-Dong,Xia, Yufei. Optimising the oil phases of aluminium hydrogel-stabilised emulsions for stable, safe and efficient vaccine adjuvant[J]. FRONTIERS OF CHEMICAL SCIENCE AND ENGINEERING,2022:12. |
| APA | Yuan, Lili,Gao, Xiao-Dong,&Xia, Yufei.(2022).Optimising the oil phases of aluminium hydrogel-stabilised emulsions for stable, safe and efficient vaccine adjuvant.FRONTIERS OF CHEMICAL SCIENCE AND ENGINEERING,12. |
| MLA | Yuan, Lili,et al."Optimising the oil phases of aluminium hydrogel-stabilised emulsions for stable, safe and efficient vaccine adjuvant".FRONTIERS OF CHEMICAL SCIENCE AND ENGINEERING (2022):12. |
入库方式： OAI收割
来源：过程工程研究所
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