Intranasal Administration of Self-Oriented Nanocarriers Based on Therapeutic Exosomes for Synergistic Treatment of Parkinson's Disease
文献类型：期刊论文
| 作者 | Peng, Huan1,2; Li, Yan3; Ji, Weihong1,2; Zhao, Ruichen1,2; Lu, Zhiguo1,2; Shen, Jie1; Wu, Yanyue1; Wang, Jianze1; Hao, Qiulian1; Wang, Jingwen1 |
| 刊名 | ACS NANO
 |
| 出版日期 | 2022-01-05 |
| 页码 | 16 |
| 关键词 | Parkinson's disease MSC-derived exosomes self-oriented nanocarrier multiple membrane barriers intranasal administration three-pronged synergistic treatment |
| ISSN号 | 1936-0851 |
| DOI | 10.1021/acsnano.1c08473 |
| 英文摘要 | The treatment of Parkinson's disease (PD) has been hindered by the complex pathologies and multiple membrane barriers during drug delivery. Although exosomes derived from mesenchymal stem cells (MSCs) have great potential for PD, MSC-derived exosomes alone could not fully meet the therapeutic requirements due to their limitation in therapy and delivery. Here, we develop a self-oriented nanocarrier called PR-EXO/PP@Cur that combines therapeutic MSC-derived exosomes with curcumin. PR-EXO/PP@Cur can be self-oriented across the multiple membrane barriers and directly release drugs into the cytoplasm of target cells after intranasal administration. With enhanced accumulation of drugs in the action site, PR-EXO/PP@Cur achieves three- pronged synergistic treatment to deal with the complex pathologies of PD by reducing a-synuclein aggregates, promoting neuron function recovery, and alleviating the neuroinflammation. After treatment with PR-EXO/PP@Cur, the movement and coordination ability of PD model mice are significantly improved. These results show that PR-EXO/PP@Cur has great prospects in treatment of PD or other neurodegenerative diseases. |
| WOS关键词 | ALPHA-SYNUCLEIN ; EXTRACELLULAR VESICLES ; COMMUNICATION ; INFLAMMATION ; MECHANISMS ; DELIVERY ; MIR-133B ; NEURONS ; CELLS |
| 资助项目 | National Natural Science Foundation of China[21905283] ; National Natural Science Foundation of China[31771095] ; National Natural Science Foundation of China[21875254] ; National Natural Science Foundation of China[32071391] ; National Natural Science Foundation of China[52073287] ; National Natural Science Foundation of China[22075289] ; Beijing Natural Science Foundation[2192057] ; Beijing Nova Program[Z201100006820140] |
| WOS研究方向 | Chemistry ; Science & Technology - Other Topics ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000742127900001 |
| 出版者 | AMER CHEMICAL SOC |
| 资助机构 | National Natural Science Foundation of China ; Beijing Natural Science Foundation ; Beijing Nova Program |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/51721]  |
| 专题 | 中国科学院过程工程研究所 |
| 通讯作者 | Zhang, Xin |
| 作者单位 | 1.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China 2.Univ Chinese Acad Sci, Beijing 100049, Peoples R China 3.Univ Sci & Technol Beijing, Sch Chem & Biol Engn, Beijing 100083, Peoples R China |
| 推荐引用方式 GB/T 7714 | Peng, Huan,Li, Yan,Ji, Weihong,et al. Intranasal Administration of Self-Oriented Nanocarriers Based on Therapeutic Exosomes for Synergistic Treatment of Parkinson's Disease[J]. ACS NANO,2022:16. |
| APA | Peng, Huan.,Li, Yan.,Ji, Weihong.,Zhao, Ruichen.,Lu, Zhiguo.,...&Zhang, Xin.(2022).Intranasal Administration of Self-Oriented Nanocarriers Based on Therapeutic Exosomes for Synergistic Treatment of Parkinson's Disease.ACS NANO,16. |
| MLA | Peng, Huan,et al."Intranasal Administration of Self-Oriented Nanocarriers Based on Therapeutic Exosomes for Synergistic Treatment of Parkinson's Disease".ACS NANO (2022):16. |
入库方式： OAI收割
来源：过程工程研究所
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