Amplifying Free Radical Generation of AIE Photosensitizer with Small Singlet-Triplet Splitting for Hypoxia-Overcoming Photodynamic Therapy
文献类型：期刊论文
| 作者 | Xiao, Ya-Fang1,2; Chen, Wen-Cheng1,2,3; Chen, Jia-Xiong1,2,3; Lu, Guihong4; Tian, Shuang1,2; Cui, Xiao1,2; Zhang, Zhen1,2; Chen, Huan1,2; Wan, Yingpeng1,2; Li, Shengliang5 |
| 刊名 | ACS APPLIED MATERIALS & INTERFACES
 |
| 出版日期 | 2022-01-20 |
| 页码 | 10 |
| 关键词 | type-I photodynamic therapy aggregate-induced emission hypoxia singlet-triplet splitting electron-rich group |
| ISSN号 | 1944-8244 |
| DOI | 10.1021/acsami.1c23797 |
| 英文摘要 | Type-I photodynamic therapy (PDT) with less oxygen consumption shows great potential for overcoming the vicious hypoxia typically observed in solid tumors. However, the development of type-I PDT is hindered by insufficient radical generation and the ambiguous design strategy of type-I photosensitizers (PSs). Therefore, developing highly efficient type-I PSs and unveiling their structure-function relationship are still urgent and challenging. Herein, we develop two phenanthro[9,10-d]imidazole derivatives (AQPO and AQPI) with aggregation-induced emission (AIE) characteristics and boost their reactive oxygen species (ROS) generation efficiency by reducing singlet-triplet splitting (Delta E-ST). Both AQPO and AQPI show ultrasmall Delta E-ST values of 0.09 and 0.12 eV, respectively. By incorporating electron-rich anisole, the categories of generated ROS by AIE PSs are changed from type-II (singlet oxygen, O-1(2)) to type-I (superoxide anion radical, O-2(center dot-) and hydroxyl radical, center dot OH). We demonstrate that the assembled AQPO nanoparticles (NPs) achieve a 3.2- and 2.9-fold increase in the O-2(center dot-) and center dot OH generation efficiencies, respectively, compared to those of AQPI NPs (without anisole) in water, whereas the O-1(2) generation efficiency of AQPO NPs is lower (0.4-fold) than that of AQPI NPs. The small Delta E-ST and anisole group endow AQPO with an excellent capacity for type-I ROS generation. In vitro and in vivo experiments show that AQPO NPs achieve an excellent hypoxia-overcoming PDT effect by efficiently eliminating tumor cells upon white light irradiation with good biosafety. |
| 资助项目 | University Grants Committee/Research Grants Council of the Hong Kong Special Administrative Region, China (Joint Laboratory Funding Scheme)[JLFS/P-101/18] ; University Grants Committee/Research Grants Council of the Hong Kong Special Administrative Region, China (General Research Fund)[CityU 11300320] ; National Natural Science Foundation of China[52173135] |
| WOS研究方向 | Science & Technology - Other Topics ; Materials Science |
| 语种 | 英语 |
| WOS记录号 | WOS:000746452200001 |
| 出版者 | AMER CHEMICAL SOC |
| 资助机构 | University Grants Committee/Research Grants Council of the Hong Kong Special Administrative Region, China (Joint Laboratory Funding Scheme) ; University Grants Committee/Research Grants Council of the Hong Kong Special Administrative Region, China (General Research Fund) ; National Natural Science Foundation of China |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/51788]  |
| 专题 | 中国科学院过程工程研究所 |
| 通讯作者 | Lu, Guihong; Li, Shengliang; Lee, Chun-Sing |
| 作者单位 | 1.City Univ Hong Kong, Ctr Super Diamond & Adv Films COSDAF, Kowloon, Hong Kong, Peoples R China 2.City Univ Hong Kong, Dept Chem, Kowloon, Hong Kong, Peoples R China 3.Guangdong Univ Technol, Sch Chem Engn & Light Ind, Guangzhou 510006, Peoples R China 4.Chinese Acad Sci, State Key Lab Biochem Engn, Inst Proc Engn, Beijing 100190, Peoples R China 5.Soochow Univ, Coll Pharmaceut Sci, Suzhou 215123, Peoples R China |
| 推荐引用方式 GB/T 7714 | Xiao, Ya-Fang,Chen, Wen-Cheng,Chen, Jia-Xiong,et al. Amplifying Free Radical Generation of AIE Photosensitizer with Small Singlet-Triplet Splitting for Hypoxia-Overcoming Photodynamic Therapy[J]. ACS APPLIED MATERIALS & INTERFACES,2022:10. |
| APA | Xiao, Ya-Fang.,Chen, Wen-Cheng.,Chen, Jia-Xiong.,Lu, Guihong.,Tian, Shuang.,...&Lee, Chun-Sing.(2022).Amplifying Free Radical Generation of AIE Photosensitizer with Small Singlet-Triplet Splitting for Hypoxia-Overcoming Photodynamic Therapy.ACS APPLIED MATERIALS & INTERFACES,10. |
| MLA | Xiao, Ya-Fang,et al."Amplifying Free Radical Generation of AIE Photosensitizer with Small Singlet-Triplet Splitting for Hypoxia-Overcoming Photodynamic Therapy".ACS APPLIED MATERIALS & INTERFACES (2022):10. |
入库方式： OAI收割
来源：过程工程研究所
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