中国科学院机构知识库网格
Chinese Academy of Sciences Institutional Repositories Grid
Local Destruction of Tumors for Systemic Immunoresponse: Engineering Antigen-Capturing Nanoparticles as Stimulus-Responsive Immunoadjuvants

文献类型:期刊论文

AuthorLu, Jingsong1,2; Guo, Zhenhu1,3; Zheng, Rong4; Xie, Wensheng1,5; Gao, Xiaohan1,6; Gao, Jianping7; Zhang, Yang7; Xu, Wanling1; Ye, Jielin1; Guo, Xiaoxiao1
SourceACS APPLIED MATERIALS & INTERFACES
Issued Date2022-01-20
Pages14
ISSN1944-8244
Keywordradio-photothermal therapy antigen-capturing abscopal effect local tumor destruction premix membrane emulsification
DOI10.1021/acsami.1c21946
English AbstractImmunotherapy has established a new paradigm for cancer treatment and made many breakthroughs in clinical practice. However, the rarity of immune response suggests that additional intervention is necessary. In recent years, it has been reported that local tumor destruction (LTD) can cause cancer cell death and induce an immunologic response. Thus, the combination of immunotherapy and LTD methods will be a promising approach to improve immune efficiency for cancer treatment. Herein, a nanobiotechnology platform to achieve high-precision LTD for systemic cancer immunotherapy has been successfully constructed. Possessing radio-sensitizing and photothermal properties, the engineered immunoadjuvant-loaded nanoplatform, which could precisely induce radiotherapy (RT)/photothermal therapy (PTT) to eliminate local tumor and meanwhile lead to the release of tumor-derived protein antigens (TDPAs), has been facilely fabricated by commercialized SPG membrane emulsification technology. Further on, the TDPAs could be captured and form personal nanovaccines in situ to serve as both reservoirs of antigen and carriers of immunoadjuvant, which can effectively improve the immune response. The investigations suggest that the combination of RT/PTT and improved immunotherapy using adjuvant-encapsulated antigen-capturing nanoparticles holds tremendous promise in cancer treatments.
WOS KeywordSPG MEMBRANE EMULSIFICATION ; CANCER ; RELEASE
Funding ProjectNational Natural Science Foundation of China[5197116] ; National Natural Science Foundation of China[81671829] ; Joint Funds for the innovation of science and Technology of Fujian province[2017Y9061] ; Joint Funds for the innovation of science and Technology of Fujian province[2017Y9050] ; Open Funding Project of the State Key Laboratory of Biochemical Engineering[2021KF-04]
WOS Research AreaScience & Technology - Other Topics ; Materials Science
Language英语
PublisherAMER CHEMICAL SOC
WOS IDWOS:000746477000001
Funding OrganizationNational Natural Science Foundation of China ; Joint Funds for the innovation of science and Technology of Fujian province ; Open Funding Project of the State Key Laboratory of Biochemical Engineering
源URL[http://ir.ipe.ac.cn/handle/122111/51902]  
Collection中国科学院过程工程研究所
Corresponding AuthorXu, Benhua; Zhang, Guifeng; Zhao, Lingyun
Affiliation1.Tsinghua Univ, Sch Mat Sci & Engn, State Key Lab New Ceram & Fine Proc, Beijing 100084, Peoples R China
2.Zhejiang Univ Technol, Res Ctr Magnet & Elect Mat, Coll Mat Sci & Engn, Hangzhou 310014, Peoples R China
3.Cent South Univ, Powder Met Res Inst, State Key Lab Powder Met, Changsha 410083, Peoples R China
4.Fujian Med Univ, Dept Radiat Oncol, Union Hosp, Fuzhou 350001, Fujian, Peoples R China
5.Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China
6.Tsinghua Univ, Dept Neurosurg, Yuquan Hosp, Sch Clin Med, Beijing 100084, Peoples R China
7.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
Recommended Citation
GB/T 7714
Lu, Jingsong,Guo, Zhenhu,Zheng, Rong,et al. Local Destruction of Tumors for Systemic Immunoresponse: Engineering Antigen-Capturing Nanoparticles as Stimulus-Responsive Immunoadjuvants[J]. ACS APPLIED MATERIALS & INTERFACES,2022:14.
APA Lu, Jingsong.,Guo, Zhenhu.,Zheng, Rong.,Xie, Wensheng.,Gao, Xiaohan.,...&Zhao, Lingyun.(2022).Local Destruction of Tumors for Systemic Immunoresponse: Engineering Antigen-Capturing Nanoparticles as Stimulus-Responsive Immunoadjuvants.ACS APPLIED MATERIALS & INTERFACES,14.
MLA Lu, Jingsong,et al."Local Destruction of Tumors for Systemic Immunoresponse: Engineering Antigen-Capturing Nanoparticles as Stimulus-Responsive Immunoadjuvants".ACS APPLIED MATERIALS & INTERFACES (2022):14.

入库方式: OAI收割

来源:过程工程研究所

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