Local Destruction of Tumors for Systemic Immunoresponse: Engineering Antigen-Capturing Nanoparticles as Stimulus-Responsive Immunoadjuvants
文献类型：期刊论文
| 作者 | Lu, Jingsong1,2; Guo, Zhenhu1,3; Zheng, Rong4; Xie, Wensheng1,5; Gao, Xiaohan1,6; Gao, Jianping7; Zhang, Yang7; Xu, Wanling1; Ye, Jielin1; Guo, Xiaoxiao1 |
| 刊名 | ACS APPLIED MATERIALS & INTERFACES
 |
| 出版日期 | 2022-01-20 |
| 页码 | 14 |
| ISSN号 | 1944-8244 |
| 关键词 | radio-photothermal therapy antigen-capturing abscopal effect local tumor destruction premix membrane emulsification |
| DOI | 10.1021/acsami.1c21946 |
| 英文摘要 | Immunotherapy has established a new paradigm for cancer treatment and made many breakthroughs in clinical practice. However, the rarity of immune response suggests that additional intervention is necessary. In recent years, it has been reported that local tumor destruction (LTD) can cause cancer cell death and induce an immunologic response. Thus, the combination of immunotherapy and LTD methods will be a promising approach to improve immune efficiency for cancer treatment. Herein, a nanobiotechnology platform to achieve high-precision LTD for systemic cancer immunotherapy has been successfully constructed. Possessing radio-sensitizing and photothermal properties, the engineered immunoadjuvant-loaded nanoplatform, which could precisely induce radiotherapy (RT)/photothermal therapy (PTT) to eliminate local tumor and meanwhile lead to the release of tumor-derived protein antigens (TDPAs), has been facilely fabricated by commercialized SPG membrane emulsification technology. Further on, the TDPAs could be captured and form personal nanovaccines in situ to serve as both reservoirs of antigen and carriers of immunoadjuvant, which can effectively improve the immune response. The investigations suggest that the combination of RT/PTT and improved immunotherapy using adjuvant-encapsulated antigen-capturing nanoparticles holds tremendous promise in cancer treatments. |
| WOS关键词 | SPG MEMBRANE EMULSIFICATION ; CANCER ; RELEASE |
| 资助项目 | National Natural Science Foundation of China[5197116] ; National Natural Science Foundation of China[81671829] ; Joint Funds for the innovation of science and Technology of Fujian province[2017Y9061] ; Joint Funds for the innovation of science and Technology of Fujian province[2017Y9050] ; Open Funding Project of the State Key Laboratory of Biochemical Engineering[2021KF-04] |
| WOS研究方向 | Science & Technology - Other Topics ; Materials Science |
| 语种 | 英语 |
| 出版者 | AMER CHEMICAL SOC |
| WOS记录号 | WOS:000746477000001 |
| 资助机构 | National Natural Science Foundation of China ; Joint Funds for the innovation of science and Technology of Fujian province ; Open Funding Project of the State Key Laboratory of Biochemical Engineering |
| 源URL | [http://ir.ipe.ac.cn/handle/122111/51902]  |
| 专题 | 中国科学院过程工程研究所 |
| 通讯作者 | Xu, Benhua; Zhang, Guifeng; Zhao, Lingyun |
| 作者单位 | 1.Tsinghua Univ, Sch Mat Sci & Engn, State Key Lab New Ceram & Fine Proc, Beijing 100084, Peoples R China 2.Zhejiang Univ Technol, Res Ctr Magnet & Elect Mat, Coll Mat Sci & Engn, Hangzhou 310014, Peoples R China 3.Cent South Univ, Powder Met Res Inst, State Key Lab Powder Met, Changsha 410083, Peoples R China 4.Fujian Med Univ, Dept Radiat Oncol, Union Hosp, Fuzhou 350001, Fujian, Peoples R China 5.Tsinghua Univ, Dept Chem, Beijing 100084, Peoples R China 6.Tsinghua Univ, Dept Neurosurg, Yuquan Hosp, Sch Clin Med, Beijing 100084, Peoples R China 7.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China |
| 推荐引用方式 GB/T 7714 | Lu, Jingsong,Guo, Zhenhu,Zheng, Rong,et al. Local Destruction of Tumors for Systemic Immunoresponse: Engineering Antigen-Capturing Nanoparticles as Stimulus-Responsive Immunoadjuvants[J]. ACS APPLIED MATERIALS & INTERFACES,2022:14. |
| APA | Lu, Jingsong.,Guo, Zhenhu.,Zheng, Rong.,Xie, Wensheng.,Gao, Xiaohan.,...&Zhao, Lingyun.(2022).Local Destruction of Tumors for Systemic Immunoresponse: Engineering Antigen-Capturing Nanoparticles as Stimulus-Responsive Immunoadjuvants.ACS APPLIED MATERIALS & INTERFACES,14. |
| MLA | Lu, Jingsong,et al."Local Destruction of Tumors for Systemic Immunoresponse: Engineering Antigen-Capturing Nanoparticles as Stimulus-Responsive Immunoadjuvants".ACS APPLIED MATERIALS & INTERFACES (2022):14. |
入库方式： OAI收割
来源：过程工程研究所
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