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Self-assembly of Fmoc-amino acids in capillary confined space forming a parallel ordered fiber network for application in vascularization

文献类型：期刊论文

作者Dong, Qianqian1,2,3; Wang, Meiyue3; Wang, Anhe3; Yu, Chunjing1,2; Bai, Shuo3; Yin, Jian2; You, Qingjun1,2
刊名BIOMATERIALS SCIENCE
出版日期2022-01-28
页码6
ISSN号2047-4830
DOI10.1039/d2bm00041e
英文摘要Matrices formed by self-assembly of amino acids and their derivatives are suitable for cell spreading, migration and proliferation, and widely used in tissue engineering and organ regeneration, due to the biological endogenous molecules and weak intermolecular forces. The self-assembly process is not only affected by dynamic and thermodynamic factors, but also the assembled space. In this work, capillary tubes with different diameters are chosen to mimic a confined environment and the effect of capillary space on the self-assembly behavior of Fmoc-amino acids with different oil-water partition coefficients (log P) was investigated. The amino acids can form special morphologies and structures through the limitation of the Brownian motion and the template effect exerted by a confined environment. Meanwhile, the obtained parallel ordered fiber network was applied to mimic the extracellular matrix (ECM) and support the adhesion and proliferation of monolayer flat epithelial cells (HUVECs). We believe that the exploration of the self-assembly of amino acids in confined space can promote the understanding of the supramolecular self-assembly mechanism and offer a great opportunity in building the specific structures of vessels or tissues in vitro.
WOS关键词PEPTIDE
资助项目Chinese Major Program for the National Key Research and Development Project[2020YFA0112603] ; project of Taihu Talent Plan ; Beijing Municipal Natural Science Foundation[7212206] ; National Natural Science Foundation of China[22072155] ; National Natural Science Foundation of China[22002170] ; Strategic Priority Research Program of the Chinese Academy of Sciences[XDA16020808]
WOS研究方向Materials Science
语种英语
WOS记录号WOS:000755738700001
出版者ROYAL SOC CHEMISTRY
资助机构Chinese Major Program for the National Key Research and Development Project ; project of Taihu Talent Plan ; Beijing Municipal Natural Science Foundation ; National Natural Science Foundation of China ; Strategic Priority Research Program of the Chinese Academy of Sciences
源URL[http://ir.ipe.ac.cn/handle/122111/51965]  
专题中国科学院过程工程研究所
通讯作者Bai, Shuo; Yin, Jian; You, Qingjun
作者单位1.Jiangnan Univ, Dept Oncol, Affiliated Hosp, Wuxi 214062, Jiangsu, Peoples R China
2.Jiangnan Univ, Sch Biotechnol, Key Lab Carbohydrate Chem & Biotechnol, Minist Educ, Wuxi 214122, Jiangsu, Peoples R China
3.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
推荐引用方式
GB/T 7714		 Dong, Qianqian,Wang, Meiyue,Wang, Anhe,et al. Self-assembly of Fmoc-amino acids in capillary confined space forming a parallel ordered fiber network for application in vascularization[J]. BIOMATERIALS SCIENCE,2022:6.
APA Dong, Qianqian.,Wang, Meiyue.,Wang, Anhe.,Yu, Chunjing.,Bai, Shuo.,...&You, Qingjun.(2022).Self-assembly of Fmoc-amino acids in capillary confined space forming a parallel ordered fiber network for application in vascularization.BIOMATERIALS SCIENCE,6.
MLA Dong, Qianqian,et al."Self-assembly of Fmoc-amino acids in capillary confined space forming a parallel ordered fiber network for application in vascularization".BIOMATERIALS SCIENCE (2022):6.

入库方式： OAI收割

来源：过程工程研究所

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