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Functional Nanomaterials Based on Self-Assembly of Endogenic NIR-Absorbing Pigments for Diagnostic and Therapeutic Applications

文献类型：期刊论文

作者Zou, Qianli1; Bao, Jianwei1; Yan, Xuehai1,2
刊名SMALL METHODS
出版日期2022-02-10
页码17
关键词endogenic pigments NIR-absorbing nanomaterials photoacoustic imaging photothermal therapy self-assembly
ISSN号2366-9608
DOI10.1002/smtd.202101359
英文摘要Endogenic pigments derived from hemoglobin have been successfully applied in the clinic for both imaging and therapy based on their inherent photophysical and photochemical properties, including light absorption, fluorescence emission, and producing reactive oxygen species. However, the clinically approved endogenic pigments can be excited only by UV/vis light, restricting the penetration depth of in vivo applications. Recently, endogenic pigments with NIR-absorbing properties have been explored for constructing functional nanomaterials. Here, the overview of NIR-absorbing endogenic pigments, mainly bile pigments, and melanins, as emerging building blocks for supramolecular construction of diagnostic and therapeutic nanomaterials is provided. The endogenic origins, synthetic pathways, and structural characteristics of the NIR-absorbing endogenic pigments are described. The self-assembling approaches and noncovalent interactions in fabricating the nanomaterials are emphasized. Since bile pigments and melanins are inherently photothermal agents, the resulting nanomaterials are demonstrated as promising candidates for photoacoustic imaging and photothermal therapy. Integration of additional diagnostic and therapeutic agents by the nanomaterials through chemical conjugation or physical encapsulation toward synergetic effects is also included. Especially, the degradation behaviors of the nanomaterials in biological environments are summarized. Along with the challenges, future perspectives are discussed for accelerating the ration design and clinical translation of NIR-absorbing nanomaterials.
WOS关键词SEMICONDUCTING POLYMER NANOPARTICLES ; CAMOUFLAGED MELANIN NANOPARTICLES ; PHOTOTHERMAL THERAPY ; BILIRUBIN NANOPARTICLES ; PHOTODYNAMIC THERAPY ; PORPHYRIN ; EFFICIENT ; PHOTOSENSITIZERS ; NANOMEDICINE ; PROTEIN
资助项目National Science Fund for Distinguished Young Scholars of China[22025207] ; National Natural Science Foundation of China[21773248] ; National Natural Science Foundation of China[21977095] ; National Natural Science Fund BRICS STI Framework Programme[51861145304] ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences (CAS)[QYZDBSSW-JSC034] ; Natural Science Foundation for Distinguished Young Scholars of Anhui Province[2108085J41] ; Grants for Scientific Research of BSKY from Anhui Medical University[XJ2020022]
WOS研究方向Chemistry ; Science & Technology - Other Topics ; Materials Science
语种英语
WOS记录号WOS:000753369300001
出版者WILEY-V C H VERLAG GMBH
资助机构National Science Fund for Distinguished Young Scholars of China ; National Natural Science Foundation of China ; National Natural Science Fund BRICS STI Framework Programme ; Key Research Program of Frontier Sciences of the Chinese Academy of Sciences (CAS) ; Natural Science Foundation for Distinguished Young Scholars of Anhui Province ; Grants for Scientific Research of BSKY from Anhui Medical University
源URL[http://ir.ipe.ac.cn/handle/122111/51973]  
专题中国科学院过程工程研究所
通讯作者Zou, Qianli; Yan, Xuehai
作者单位1.Anhui Med Univ, Sch Pharm, Hefei 230032, Peoples R China
2.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
推荐引用方式
GB/T 7714		 Zou, Qianli,Bao, Jianwei,Yan, Xuehai. Functional Nanomaterials Based on Self-Assembly of Endogenic NIR-Absorbing Pigments for Diagnostic and Therapeutic Applications[J]. SMALL METHODS,2022:17.
APA Zou, Qianli,Bao, Jianwei,&Yan, Xuehai.(2022).Functional Nanomaterials Based on Self-Assembly of Endogenic NIR-Absorbing Pigments for Diagnostic and Therapeutic Applications.SMALL METHODS,17.
MLA Zou, Qianli,et al."Functional Nanomaterials Based on Self-Assembly of Endogenic NIR-Absorbing Pigments for Diagnostic and Therapeutic Applications".SMALL METHODS (2022):17.

入库方式： OAI收割

来源：过程工程研究所

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