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Effectively Converting Cane Molasses into 2,3-Butanediol Using Clostridium ljungdahlii by an Integrated Fermentation and Membrane Separation Process

文献类型：期刊论文

作者Yang, Yuling1,2; Deng, Tingting3; Cao, Weifeng2,4; Shen, Fei2,4; Liu, Sijia1; Zhang, Jing1; Liang, Xinquan1; Wan, Yinhua2,4
刊名MOLECULES
出版日期2022-02-01
卷号27期号:3页码:15
关键词2 3-butanediol Clostridium ljungdahlii cane molasses membrane separation
DOI10.3390/molecules27030954
英文摘要Firstly, 2,3-butanediol (2,3-BDO) is a chemical platform used in several applications. However, the pathogenic nature of its producers and the expensive feedstocks used limit its scale production. In this study, cane molasses was used for 2,3-BDO production by a nonpathogenic Clostridium ljungdahlii. It was found that cane molasses alone, without the addition of other ingredients, was favorable for use as the culture medium for 2,3-BDO production. Compared with the control (i.e., the modified DSMZ 879 medium), the differential genes are mainly involved in the pathways of carbohydrate metabolism, membrane transport, and amino acid metabolism in the case of the cane molasses alone. However, when cane molasses alone was used, cell growth was significantly inhibited by KCl in cane molasses. Similarly, a high concentration of sugars (i.e., above 35 g/L) can inhibit cell growth and 2,3-BDO production. More seriously, 2,3-BDO production was inhibited by itself. As a result, cane molasses alone with an initial 35 g/L total sugars was suitable for 2,3-BDO production in batch culture. Finally, an integrated fermentation and membrane separation process was developed to maintain high 2,3-BDO productivity of 0.46 g center dot L-1 center dot h(-1). Meanwhile, the varied fouling mechanism indicated that the fermentation properties changed significantly, especially for the cell properties. Therefore, the integrated fermentation and membrane separation process was favorable for 2,3-BDO production by C. ljungdahlii using cane molasses.
WOS关键词ACTINOBACILLUS-SUCCINOGENES ; AUREOBASIDIUM-PULLULANS ; SUCCINIC ACID ; KLEBSIELLA ; GLYCEROL ; ULTRAFILTRATION ; ENTEROBACTER ; DECOLORATION ; MECHANISMS ; ACETOIN
资助项目Beijing Natural Science Foundation, China[5182025] ; National Natural Science Foundation of China, China[21406240] ; National High Technology Research and Development Program of China[2015AA021002] ; National High Technology Research and Development Program of China[2014AA021005]
WOS研究方向Biochemistry & Molecular Biology ; Chemistry
语种英语
出版者MDPI
WOS记录号WOS:000759163500001
资助机构Beijing Natural Science Foundation, China ; National Natural Science Foundation of China, China ; National High Technology Research and Development Program of China
源URL[http://ir.ipe.ac.cn/handle/122111/52016]  
专题中国科学院过程工程研究所
通讯作者Cao, Weifeng; Liang, Xinquan
作者单位1.Guangxi Univ, Coll Light Ind & Food Engn, Dept Sugar Engn, Nanning 530004, Peoples R China
2.Chinese Acad Sci, Inst Proc Engn, State Key Lab Biochem Engn, Beijing 100190, Peoples R China
3.Chinese Acad Inspect & Quarantine, Agro Prod Safety Res Ctr, Beijing 100123, Peoples R China
4.Univ Chinese Acad Sci, Sch Chem Engn, Beijing 100049, Peoples R China
推荐引用方式
GB/T 7714		 Yang, Yuling,Deng, Tingting,Cao, Weifeng,et al. Effectively Converting Cane Molasses into 2,3-Butanediol Using Clostridium ljungdahlii by an Integrated Fermentation and Membrane Separation Process[J]. MOLECULES,2022,27(3):15.
APA Yang, Yuling.,Deng, Tingting.,Cao, Weifeng.,Shen, Fei.,Liu, Sijia.,...&Wan, Yinhua.(2022).Effectively Converting Cane Molasses into 2,3-Butanediol Using Clostridium ljungdahlii by an Integrated Fermentation and Membrane Separation Process.MOLECULES,27(3),15.
MLA Yang, Yuling,et al."Effectively Converting Cane Molasses into 2,3-Butanediol Using Clostridium ljungdahlii by an Integrated Fermentation and Membrane Separation Process".MOLECULES 27.3(2022):15.

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来源：过程工程研究所

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