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Decellularized Pig Kidney with a Micro-Nano Secondary Structure Contributes to Tumor Progression in 3D Tumor Model

文献类型：期刊论文

作者Yang, Shuangjia1; Zheng, Le1; Chen, Zilong1; Jiao, Zeren2; Liu, Tianqing1; Nie, Yi3,4; Kang, Yue5; Pan, Bo6; Song, Kedong1
刊名MATERIALS
出版日期2022-03-01
卷号15期号:5页码:20
关键词extracellular matrix derived scaffolds pig kidney micro-nano secondary structure tumor model
DOI10.3390/ma15051935
英文摘要In spite of many anti-cancer drugs utilized in clinical treatment, cancer is still one of the diseases with the highest morbidity and mortality worldwide, owing to the complexity and heterogeneity of the tumor microenvironment. Compared with conventional 2D tumor models, 3D scaffolds could provide structures and a microenvironment which stimulate native tumor tissues more accurately. The extracellular matrix (ECM) is the main component of the cell in the microenvironment that is mainly composed of three-dimensional nanofibers, which can form nanoscale fiber networks, while the decellularized extracellular matrix (dECM) has been widely applied to engineered scaffolds. In this study, pig kidney was used as the source material to prepare dECM scaffolds. A chemical crosslinking method was used to improve the mechanical properties and other physical characteristics of the decellularized pig kidney-derived scaffold. Furthermore, a human breast cancer cell line (MCF-7) was used to further investigate the biocompatibility of the scaffold to fabricate a tumor model. The results showed that the existence of nanostructures in the scaffold plays an important role in cell adhesion, proliferation, and differentiation. Therefore, the pig kidney-derived matrix scaffold prepared by decellularization could provide more cell attachment sites, which is conducive to cell adhesion and proliferation, physiological activities, and tumor model construction.
WOS关键词EXTRACELLULAR-MATRIX ; IN-VITRO ; TISSUE ; BIOMATERIALS ; SCAFFOLDS ; POLYMER ; CANCER ; FIBRIN ; DRUG ; PEG
资助项目National Natural Science Foundation of China[31670978] ; State Key Laboratory of Fine Chemicals[KF1111] ; Fundamental Research Funds for the Central Universities[DUT20ZD206/DUT20YG118/DUT21YG113]
WOS研究方向Chemistry ; Materials Science ; Metallurgy & Metallurgical Engineering ; Physics
语种英语
出版者MDPI
WOS记录号WOS:000769142600001
资助机构National Natural Science Foundation of China ; State Key Laboratory of Fine Chemicals ; Fundamental Research Funds for the Central Universities
源URL[http://ir.ipe.ac.cn/handle/122111/52213]  
专题中国科学院过程工程研究所
通讯作者Nie, Yi; Kang, Yue; Pan, Bo; Song, Kedong
作者单位1.Dalian Univ Technol, Dalian R&D Ctr Stem Cell & Tissue Engn, State Key Lab Fine Chem, Dalian 116024, Peoples R China
2.Texas A&M Univ, Artie McFerrin Dept Chem Engn, College Stn, TX 77843 USA
3.Zhengzhou Inst Emerging Ind Technol, Zhengzhou 450000, Peoples R China
4.Chinese Acad Sci, Inst Proc Engn, Key Lab Green Proc & Engn, Beijing 100190, Peoples R China
5.Canc Hosp China Med Univ, Dept Breast Surg, 44 Xiaoheyan Rd, Shenyang 110042, Peoples R China
6.Dalian Med Univ, Dept Breast Surg, Hosp 2, 467 Zhongshan Rd, Dalian 116023, Peoples R China
推荐引用方式
GB/T 7714		 Yang, Shuangjia,Zheng, Le,Chen, Zilong,et al. Decellularized Pig Kidney with a Micro-Nano Secondary Structure Contributes to Tumor Progression in 3D Tumor Model[J]. MATERIALS,2022,15(5):20.
APA Yang, Shuangjia.,Zheng, Le.,Chen, Zilong.,Jiao, Zeren.,Liu, Tianqing.,...&Song, Kedong.(2022).Decellularized Pig Kidney with a Micro-Nano Secondary Structure Contributes to Tumor Progression in 3D Tumor Model.MATERIALS,15(5),20.
MLA Yang, Shuangjia,et al."Decellularized Pig Kidney with a Micro-Nano Secondary Structure Contributes to Tumor Progression in 3D Tumor Model".MATERIALS 15.5(2022):20.

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来源：过程工程研究所

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